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1-oxo-steroids. Part 2. Model studies for the synthesis of the withanolides
Year:
1977
Authors :
ויסנברג, מרטין
;
.
Volume :
Co-Authors:
Weissenberg, M., Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel
Lavie, D., Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel
Glotter, E., Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel
Facilitators :
From page:
795
To page:
801
(
Total pages:
7
)
Abstract:
Several cholestane derivatives possessing rings A and B with the same substitution pattern as in the naturally occurring steroidal lactones of the withanolide group have been synthesised: 4β-hydroxycholesta-2,5-dien-1-one (10), 5,6β-epoxy-4β-hydroxy-5β-cholest-2-en-1-one (12), cholesta-2,5-dien-1-one (19), and 5,6β-epoxy-5β-cholest-2-en-1-one (21). Several other compounds in which rings A and B have a substitution pattern not yet encountered among the natural withanolides have also been prepared: 5,6α-epoxy-4β-hydroxy-5α-cholest-2-en-1-one (11), 5,6α-epoxy-5α-cholest-2-en-1-one (20), and 4α-acetoxy-5- hydroxy-5β-cholest-2-en-1-one (28).
Note:
Related Files :
article
chemical model
cholest 4 en 3 one
cholestane derivative
Cholestenones
lactone
Models, Chemical
Synthesis
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
18568
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:22
Scientific Publication
1-oxo-steroids. Part 2. Model studies for the synthesis of the withanolides
Weissenberg, M., Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel
Lavie, D., Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel
Glotter, E., Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel
1-oxo-steroids. Part 2. Model studies for the synthesis of the withanolides
Several cholestane derivatives possessing rings A and B with the same substitution pattern as in the naturally occurring steroidal lactones of the withanolide group have been synthesised: 4β-hydroxycholesta-2,5-dien-1-one (10), 5,6β-epoxy-4β-hydroxy-5β-cholest-2-en-1-one (12), cholesta-2,5-dien-1-one (19), and 5,6β-epoxy-5β-cholest-2-en-1-one (21). Several other compounds in which rings A and B have a substitution pattern not yet encountered among the natural withanolides have also been prepared: 5,6α-epoxy-4β-hydroxy-5α-cholest-2-en-1-one (11), 5,6α-epoxy-5α-cholest-2-en-1-one (20), and 4α-acetoxy-5- hydroxy-5β-cholest-2-en-1-one (28).
Scientific Publication
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