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פותח על ידי קלירמאש פתרונות בע"מ -
The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast
Year:
1999
Authors :
שרמן, עמיר
;
.
Volume :
96
Co-Authors:
Gaxiola, R.A., Whitehead Inst. for Biomed. Research, Massachusetts Inst. of Technology, 9 Cambridge Center, Cambridge, MA 02142-1479, United States
Rao, R., Johns Hopkins University, School of Medicine, Department of Physiology, 725 North Wolfe Street, Baltimore, MD 21205, United States
Sherman, A., Whitehead Inst. for Biomed. Research, Massachusetts Inst. of Technology, 9 Cambridge Center, Cambridge, MA 02142-1479, United States
Grisafi, P., Whitehead Inst. for Biomed. Research, Massachusetts Inst. of Technology, 9 Cambridge Center, Cambridge, MA 02142-1479, United States
Alper, S.L., Harvard Medical School, Molecular Medicine and Renal Units, RW763 Beth Israel Deaconess Med. C., 330 Brookline Avenue, Boston, MA 02215, United States
Fink, G.R., Whitehead Inst. for Biomed. Research, Massachusetts Inst. of Technology, 9 Cambridge Center, Cambridge, MA 02142-1479, United States
Facilitators :
From page:
1480
To page:
1485
(
Total pages:
6
)
Abstract:
Overexpression of the Arabidopsis thaliana vacuolar H+-pyrophosphatase (AVP1) confers salt tolerance to the salt-sensitive ena1 mutant of Saccharomyces cerevisiae. Suppression of salt sensitivity requires two ion transporters, the Gef1 Cl- channel and the Nhx1 Na+/H+ exchanger. These two proteins colocalize to the prevacuolar compartment of yeast and are thought to be required for optimal acidification of this compartment. Overexpression of AtNHX1, the plant homologue of the yeast Na+/H+ exchanger, suppresses some of the mutant phenotypes of the yeast nhx1 mutant. Moreover, the level of AtNHX1 mRNA in Arabidopsis is increased in the presence of NaCl. The regulation of AtNHX1 by NaCl and the ability of the plant gene to suppress the yeast nhx1 mutant suggest that the mechanism by which cations are detoxified in yeast and plants may be similar.
Note:
Related Files :
arabidopsis
Arabidopsis thaliana
Gene
inorganic pyrophosphatase
Saccharomyces cerevisiae Proteins
עוד תגיות
תוכן קשור
More details
DOI :
10.1073/pnas.96.4.1480
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
18617
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:23
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Scientific Publication
The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast
96
Gaxiola, R.A., Whitehead Inst. for Biomed. Research, Massachusetts Inst. of Technology, 9 Cambridge Center, Cambridge, MA 02142-1479, United States
Rao, R., Johns Hopkins University, School of Medicine, Department of Physiology, 725 North Wolfe Street, Baltimore, MD 21205, United States
Sherman, A., Whitehead Inst. for Biomed. Research, Massachusetts Inst. of Technology, 9 Cambridge Center, Cambridge, MA 02142-1479, United States
Grisafi, P., Whitehead Inst. for Biomed. Research, Massachusetts Inst. of Technology, 9 Cambridge Center, Cambridge, MA 02142-1479, United States
Alper, S.L., Harvard Medical School, Molecular Medicine and Renal Units, RW763 Beth Israel Deaconess Med. C., 330 Brookline Avenue, Boston, MA 02215, United States
Fink, G.R., Whitehead Inst. for Biomed. Research, Massachusetts Inst. of Technology, 9 Cambridge Center, Cambridge, MA 02142-1479, United States
The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast
Overexpression of the Arabidopsis thaliana vacuolar H+-pyrophosphatase (AVP1) confers salt tolerance to the salt-sensitive ena1 mutant of Saccharomyces cerevisiae. Suppression of salt sensitivity requires two ion transporters, the Gef1 Cl- channel and the Nhx1 Na+/H+ exchanger. These two proteins colocalize to the prevacuolar compartment of yeast and are thought to be required for optimal acidification of this compartment. Overexpression of AtNHX1, the plant homologue of the yeast Na+/H+ exchanger, suppresses some of the mutant phenotypes of the yeast nhx1 mutant. Moreover, the level of AtNHX1 mRNA in Arabidopsis is increased in the presence of NaCl. The regulation of AtNHX1 by NaCl and the ability of the plant gene to suppress the yeast nhx1 mutant suggest that the mechanism by which cations are detoxified in yeast and plants may be similar.
Scientific Publication
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