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פותח על ידי קלירמאש פתרונות בע"מ -
Diuretic action and immunological cross-reactivity of corticotropin and locust diuretic hormone
Year:
1987
Authors :
רפאלי, עדה
;
.
Volume :
67
Co-Authors:
Rafaeli, A., Department of Entomology, Faculty of Agriculture, Rehovot 76-100, Israel
Moshitzky, P., Department of Entomology, Faculty of Agriculture, Rehovot 76-100, Israel
Applebaum, S.W., Department of Entomology, Faculty of Agriculture, Rehovot 76-100, Israel
Facilitators :
From page:
1
To page:
6
(
Total pages:
6
)
Abstract:
A functional similarity and immunological cross-reactivity between adrenocorticotrophic hormone (ACTH) and a locust diuretic hormone (DH) is reported. The functional similarity is expressed in that ACTH mimics DH by stimulating fluid secretion and cyclic AMP (cAMP) secretion in locust Malpighian tubules. Desacetyl-α-melanocyte-stimulating hormone is active to a lesser degree but no other POMC-derived peptide tested was found to follow suit. Immunological cross-reactivity is shown by a positive response of HPLC-purified DH with a specific ACTH radioimmunoassay as well as a significant reduction in DH activity (fluid secretion) after incubations with ACTH antiserum. However, ACTH and DH are different peptides since they do not share common separation characteristics on HPLC and ACTH does not induce a high excess secretion of cAMP by the tubule cell as does DH. © 1987.
Note:
Related Files :
Animal
Cross Reactions
hemolymph
human
insect hormones
Male
Malpighian Tubules
Pro-Opiomelanocortin
radioimmunoassay
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/0016-6480(87)90199-7
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
18852
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:24
Scientific Publication
Diuretic action and immunological cross-reactivity of corticotropin and locust diuretic hormone
67
Rafaeli, A., Department of Entomology, Faculty of Agriculture, Rehovot 76-100, Israel
Moshitzky, P., Department of Entomology, Faculty of Agriculture, Rehovot 76-100, Israel
Applebaum, S.W., Department of Entomology, Faculty of Agriculture, Rehovot 76-100, Israel
Diuretic action and immunological cross-reactivity of corticotropin and locust diuretic hormone
A functional similarity and immunological cross-reactivity between adrenocorticotrophic hormone (ACTH) and a locust diuretic hormone (DH) is reported. The functional similarity is expressed in that ACTH mimics DH by stimulating fluid secretion and cyclic AMP (cAMP) secretion in locust Malpighian tubules. Desacetyl-α-melanocyte-stimulating hormone is active to a lesser degree but no other POMC-derived peptide tested was found to follow suit. Immunological cross-reactivity is shown by a positive response of HPLC-purified DH with a specific ACTH radioimmunoassay as well as a significant reduction in DH activity (fluid secretion) after incubations with ACTH antiserum. However, ACTH and DH are different peptides since they do not share common separation characteristics on HPLC and ACTH does not induce a high excess secretion of cAMP by the tubule cell as does DH. © 1987.
Scientific Publication
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