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פותח על ידי קלירמאש פתרונות בע"מ -
Ultrafast 2D NMR spectroscopy using sinusoidal gradients: Principles and ex vivo brain investigations
Year:
2004
Source of publication :
Magnetic Resonance in Medicine
Authors :
סלע, נעה
;
.
Volume :
52
Co-Authors:
Sela, N., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
Degani, H., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
Frydman, L., Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
Facilitators :
From page:
893
To page:
897
(
Total pages:
5
)
Abstract:
A new methodology capable of delivering complete 2D NMR spectra within a single scan was recently introduced. The resulting potential gain in time resolution could open new opportunities for in vivo spectroscopy, provided that the technical demands of the methodology are satisfied by the corresponding hardware. Foremost among these demands are the relatively short switching times expected from the applied gradient-echo trains. These rapid transitions may be particularly difficult to accomplish on imaging systems. As a step toward solving this problem, we assessed the possibility of replacing the square-wave gradient train currently used during the course of the acquisition by a shaped sinusoidal gradient. Examples of the implementation of this protocol are given, and successful ultrafast acquisitions of 2D NMR spectra with suitable spectral widths on a microimaging probe (for both phantom solutions and ex vivo mouse brains) are demonstrated. © 2004 Wiley-Liss, Inc.
Note:
Related Files :
Animals
animal tissue
Brain metabolites
Feasibility Studies
intermethod comparison
mice
phantom
Sinusoidal gradients
עוד תגיות
תוכן קשור
More details
DOI :
10.1002/mrm.20204
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
18985
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:25
Scientific Publication
Ultrafast 2D NMR spectroscopy using sinusoidal gradients: Principles and ex vivo brain investigations
52
Sela, N., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
Degani, H., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
Frydman, L., Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
Ultrafast 2D NMR spectroscopy using sinusoidal gradients: Principles and ex vivo brain investigations
A new methodology capable of delivering complete 2D NMR spectra within a single scan was recently introduced. The resulting potential gain in time resolution could open new opportunities for in vivo spectroscopy, provided that the technical demands of the methodology are satisfied by the corresponding hardware. Foremost among these demands are the relatively short switching times expected from the applied gradient-echo trains. These rapid transitions may be particularly difficult to accomplish on imaging systems. As a step toward solving this problem, we assessed the possibility of replacing the square-wave gradient train currently used during the course of the acquisition by a shaped sinusoidal gradient. Examples of the implementation of this protocol are given, and successful ultrafast acquisitions of 2D NMR spectra with suitable spectral widths on a microimaging probe (for both phantom solutions and ex vivo mouse brains) are demonstrated. © 2004 Wiley-Liss, Inc.
Scientific Publication
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