Co-Authors:
Borisover, M.D., Kazan State University, Department of Chemistry, 420008 Kazan, Russian Federation
Sirotkin, V.A., Kazan State University, Department of Chemistry, 420008 Kazan, Russian Federation
Solomonov, B.N., Kazan State University, Department of Chemistry, 420008 Kazan, Russian Federation
Abstract:
Heat effects resulting from the introduction of solid human serum albumin (HSA) into various water-acetonitrile mixtures were measured calorimetrically at 298 K. The amount of water bound to the suspended HSA as a function of the water content of the solvent was also determined. Introducing HSA into water-acetonitrile mixtures involves water binding according to the Langmuir isotherm with an adsorption constant Kc = 1.0 ± 0.1 M-1, enthalpy Δh = -9.0 ± 1.5 kJ mol-1 and entropy ΔS = -30 ± 6 J mol-1 K-1. Placing HSA in the solvent has an additional heat effect of 46 ± 19 J g-1, which is attributed to an unknown transformation of the protein preparation. © 1995.
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