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פותח על ידי קלירמאש פתרונות בע"מ -
Quantitative stereoisomeric determination of phenylpropylamino alkaloids in khat (catha edulis forsk.) using chiral GC-MS
Year:
2008
Source of publication :
Israel Journal of Plant Sciences
Authors :
בר, עינת
;
.
דודאי, נתיב
;
.
דסאו, אילנה
;
.
לוינסון, אפרים
;
.
קריזבסקי, רז
;
.
רביד, עוזי
;
.
Volume :
56
Co-Authors:
Krizevski, R., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel, Albert Katz Department of Dryland Agriculture, Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sede Boqer 84990, Israel
Dudai, N., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Bar, E., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Dessow, I., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel, Department of Life Sciences, Ben-Gurion University of the Negev, P.O. Box 653, Be'er Sheva 84105, Israel
Ravid, U., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Lewinsohna, E., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Facilitators :
From page:
207
To page:
213
(
Total pages:
7
)
Abstract:
Khat (Catha edulis Forsk., Celastraceae) is a perennial shrub that was introduced to Israel by Yemenite immigrants. Its young leaves are chewed for their psychostimulating properties. Young khat leaves contain the phenylpropylamino alkaloids (-)-cathinone [(S)-α-aminopropiophenone], (+)-cathine [(1S)(2S)-norpseudoephedrine], and (-)-norephedrine [(1R)(2S)-norephedrine] as the main active principles. A novel GC-MS analysis method for the quantitative determination of phenylpropylamino alkaloids and their putative biosynthetic precursor 1-phenylpropane-1,2- dione in khat leaves was developed. We utilized an alkaline-organic extraction, coupled with gas chromatography and a chiral permethylated beta cyclodextrin phase, to allow a full separation between the two diastereoisomers (1S)(2S)-cathineand (1R)(2S)-norephedrine. We found a marked diversity in the phenylpropylamino alkaloid content and composition in three different locally grown accessions and the commercial cultivar 'Mahanaim. Copyright © 2008 Science From Israel / LPPltd.
Note:
Related Files :
alkaloid
Catha edulis
cathinone
Gas Chromatography
Khat
norephedrine
phenylpropylamino alkaloids
quantitative analysis
shrub
עוד תגיות
תוכן קשור
More details
DOI :
10.1560/IJPS.56.3.207
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
19220
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:27
You may also be interested in
Scientific Publication
Quantitative stereoisomeric determination of phenylpropylamino alkaloids in khat (catha edulis forsk.) using chiral GC-MS
56
Krizevski, R., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel, Albert Katz Department of Dryland Agriculture, Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sede Boqer 84990, Israel
Dudai, N., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Bar, E., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Dessow, I., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel, Department of Life Sciences, Ben-Gurion University of the Negev, P.O. Box 653, Be'er Sheva 84105, Israel
Ravid, U., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Lewinsohna, E., Department of Aromatic, Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Quantitative stereoisomeric determination of phenylpropylamino alkaloids in khat (catha edulis forsk.) using chiral GC-MS
Khat (Catha edulis Forsk., Celastraceae) is a perennial shrub that was introduced to Israel by Yemenite immigrants. Its young leaves are chewed for their psychostimulating properties. Young khat leaves contain the phenylpropylamino alkaloids (-)-cathinone [(S)-α-aminopropiophenone], (+)-cathine [(1S)(2S)-norpseudoephedrine], and (-)-norephedrine [(1R)(2S)-norephedrine] as the main active principles. A novel GC-MS analysis method for the quantitative determination of phenylpropylamino alkaloids and their putative biosynthetic precursor 1-phenylpropane-1,2- dione in khat leaves was developed. We utilized an alkaline-organic extraction, coupled with gas chromatography and a chiral permethylated beta cyclodextrin phase, to allow a full separation between the two diastereoisomers (1S)(2S)-cathineand (1R)(2S)-norephedrine. We found a marked diversity in the phenylpropylamino alkaloid content and composition in three different locally grown accessions and the commercial cultivar 'Mahanaim. Copyright © 2008 Science From Israel / LPPltd.
Scientific Publication
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