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פותח על ידי קלירמאש פתרונות בע"מ -
Effects of chronic arachidonate on blood pressure of spontaneously hypertensive rats
Year:
1983
Authors :
עזרא, דוד
;
.
Volume :
A5
Co-Authors:
Ezra, D., Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, United States
Bayorh, M.A., Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, United States
Zukowska-Grojec, Z., Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, United States
Lazar, J.D., Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, United States
Kopin, I.J., Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, United States
Feuerstein, G., Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20205, United States
Facilitators :
From page:
1485
To page:
1499
(
Total pages:
15
)
Abstract:
Three weeks of treatment with arachidonic acid (250 mg/kg/day, s.c.) produced an antihypertensive effect in 16 week-old spontaneously hypertensive rats (SHR) as compared with vehicle treated rats. Indomethacin (4 mg/kg, s.c. B.I.D.), given concurrently with arachidonate, abolished the antihypertensive effect. Plasma catecholamines were not altered by the arachidonate treatment, but blood pressure increments after spinal cord stimulation or after intravenous administration of norepinephrine and angiotensin II in the pithed rat were diminished. Increments in plasma catecholamines in response to spinal cord stimulation were similar in both groups of pithed rats. These data demonstrate the antihypertensive effect of arachidonic acid in SHR with established hypertension. This beneficial effect seems to be mediated through cyclooxygenase metabolites, and might be related to reduced responsiveness of peripheral blood vessels to pressor stimuli. © 1983 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Note:
Related Files :
Angiotensin II
Animal
animal model
cardiovascular system
Hypertension
Male
Norepinephrine
Spontaneously hypertensive rats
עוד תגיות
תוכן קשור
More details
DOI :
10.3109/10641968309069506
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
19254
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:27
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Scientific Publication
Effects of chronic arachidonate on blood pressure of spontaneously hypertensive rats
A5
Ezra, D., Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, United States
Bayorh, M.A., Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, United States
Zukowska-Grojec, Z., Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, United States
Lazar, J.D., Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, United States
Kopin, I.J., Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, United States
Feuerstein, G., Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20205, United States
Effects of chronic arachidonate on blood pressure of spontaneously hypertensive rats
Three weeks of treatment with arachidonic acid (250 mg/kg/day, s.c.) produced an antihypertensive effect in 16 week-old spontaneously hypertensive rats (SHR) as compared with vehicle treated rats. Indomethacin (4 mg/kg, s.c. B.I.D.), given concurrently with arachidonate, abolished the antihypertensive effect. Plasma catecholamines were not altered by the arachidonate treatment, but blood pressure increments after spinal cord stimulation or after intravenous administration of norepinephrine and angiotensin II in the pithed rat were diminished. Increments in plasma catecholamines in response to spinal cord stimulation were similar in both groups of pithed rats. These data demonstrate the antihypertensive effect of arachidonic acid in SHR with established hypertension. This beneficial effect seems to be mediated through cyclooxygenase metabolites, and might be related to reduced responsiveness of peripheral blood vessels to pressor stimuli. © 1983 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Scientific Publication
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