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פותח על ידי קלירמאש פתרונות בע"מ -
Molecular cloning and properties of the chicken leptin-receptor (CLEPR) gene
Year:
2000
Authors :
אהרוני, תומר
;
.
אשדת, יובל
;
.
חורב, גיא
;
.
Volume :
162
Co-Authors:
Horev, G., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P., Bet Dagan, Israel
Einat, P., QBI Enterprises Ltd, 70400, Nes-Ziona, Israel
Aharoni, T., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P., Bet Dagan, Israel
Eshdat, Y., Institute of Horticulture, Agric. Res. Org., Volcani Ctr., P., Bet Dagan, Israel
Friedman-Einat, M., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P., Bet Dagan, Israel
Facilitators :
From page:
95
To page:
106
(
Total pages:
12
)
Abstract:
The mammalian leptin receptor (LEPR) (formerly OB-R) mediates the weight regulatory effects of the circulating hormone leptin. The extreme obese phenotype of recessive mutations in the mouse leptin or LEPR genes (ob/ob and db/db mice, respectively) indicate the high potential of these genes for medical and agricultural research. In this paper, we report on the cloning of the full-length chicken leptin receptor (CLEPR) cDNA, which is the first non- mammalian cloning of a LEPR gene. The CLEPR gene shares a relatively low sequence similarity with its mammalian counterparts, with an average of 60% identical nucleotides. However, comparison between the predicted protein sequences has shown a tight conservation of most previously characterized LEPR motifs and essential tyrosine residues. Similarities between the chicken and the mammalian LEPR genes were also observed in the pattern of mRNA expression. The identification of the CLEPR gene should facilitate the study of the molecular mechanism involved in the regulation of body growth and composition in avian. (C) 2000 Elsevier Science Ireland Ltd.
Note:
Related Files :
Animals
animal tissue
cattle
gene expression
Leptin receptor (LEPR, OB-R)
mice
mutation
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/S0303-7207(00)00205-7
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
19820
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:31
You may also be interested in
Scientific Publication
Molecular cloning and properties of the chicken leptin-receptor (CLEPR) gene
162
Horev, G., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P., Bet Dagan, Israel
Einat, P., QBI Enterprises Ltd, 70400, Nes-Ziona, Israel
Aharoni, T., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P., Bet Dagan, Israel
Eshdat, Y., Institute of Horticulture, Agric. Res. Org., Volcani Ctr., P., Bet Dagan, Israel
Friedman-Einat, M., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P., Bet Dagan, Israel
Molecular cloning and properties of the chicken leptin-receptor (CLEPR) gene
The mammalian leptin receptor (LEPR) (formerly OB-R) mediates the weight regulatory effects of the circulating hormone leptin. The extreme obese phenotype of recessive mutations in the mouse leptin or LEPR genes (ob/ob and db/db mice, respectively) indicate the high potential of these genes for medical and agricultural research. In this paper, we report on the cloning of the full-length chicken leptin receptor (CLEPR) cDNA, which is the first non- mammalian cloning of a LEPR gene. The CLEPR gene shares a relatively low sequence similarity with its mammalian counterparts, with an average of 60% identical nucleotides. However, comparison between the predicted protein sequences has shown a tight conservation of most previously characterized LEPR motifs and essential tyrosine residues. Similarities between the chicken and the mammalian LEPR genes were also observed in the pattern of mRNA expression. The identification of the CLEPR gene should facilitate the study of the molecular mechanism involved in the regulation of body growth and composition in avian. (C) 2000 Elsevier Science Ireland Ltd.
Scientific Publication
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