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פותח על ידי קלירמאש פתרונות בע"מ -
Stat5 in the mammary gland: Controlling normal development and cancer
Year:
2006
Source of publication :
Journal of Cellular Physiology
Authors :
ברש, איתמר
;
.
Volume :
209
Co-Authors:
Barash, I., Institute of Animal Science, ARO, Volcani Center, Bet-Dagan, Israel, Institute of Animal Science, ARO, Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel
Facilitators :
From page:
305
To page:
313
(
Total pages:
9
)
Abstract:
The signal transducer and activator of transcription (Stat5) funnels extracellular signals of cytokines, hormones, and growth factors into transcriptional activity in the mammary gland. Postnatal development and functionality of this tissue is synchronized with the reproductive cycle. Consequently, Stat5 involvement in lobuloalveolar development, milk-protein synthesis, or tissue remodeling is dictated by the particular reproductive stage. Latent deregulation of Stat5 activity during the reproductive cycle predisposes the tissue to tumorigenesis at a later stage, when the female is no longer fertile. Accumulating data from studies with mouse models and breast-cancer specimens demonstrate a dual role for Stat5 in this context. It causes tumorigenesis, but delays metastasis progression. Consequently, Stat5 activity in breast-cancer specimens marks a better prognosis for survival. © 2006 Wiley-Liss, Inc.
Note:
Related Files :
Animals
breast cancer
Carcinogenesis
Female
lung development
Models, Biological
Review
עוד תגיות
תוכן קשור
More details
DOI :
10.1002/jcp.20771
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
סקירה
;
.
Language:
אנגלית
Editors' remarks:
ID:
19864
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:32
You may also be interested in
Scientific Publication
Stat5 in the mammary gland: Controlling normal development and cancer
209
Barash, I., Institute of Animal Science, ARO, Volcani Center, Bet-Dagan, Israel, Institute of Animal Science, ARO, Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel
Stat5 in the mammary gland: Controlling normal development and cancer
The signal transducer and activator of transcription (Stat5) funnels extracellular signals of cytokines, hormones, and growth factors into transcriptional activity in the mammary gland. Postnatal development and functionality of this tissue is synchronized with the reproductive cycle. Consequently, Stat5 involvement in lobuloalveolar development, milk-protein synthesis, or tissue remodeling is dictated by the particular reproductive stage. Latent deregulation of Stat5 activity during the reproductive cycle predisposes the tissue to tumorigenesis at a later stage, when the female is no longer fertile. Accumulating data from studies with mouse models and breast-cancer specimens demonstrate a dual role for Stat5 in this context. It causes tumorigenesis, but delays metastasis progression. Consequently, Stat5 activity in breast-cancer specimens marks a better prognosis for survival. © 2006 Wiley-Liss, Inc.
Scientific Publication
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