Co-Authors:
LEZNOFF, C.C., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
VIGH, S., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
SVIRSKAYA, P.I., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
GREENBERG, S., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
DREW, D.M., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
BEN‐HUR, E., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
ROSENTHAL, I., Department of Food Science, A.R.O, Volcani Center, P.O. Box 6, Bet Dagan, Israel
Abstract:
Abstract Some new, ring‐substituted phthalocyanines have been synthesized and underwent preliminary testing for photodynamic activity using the colony forming ability of Chinese hamster cells in culture as an endpoint. Using 4‐(3‐N, N‐diethylaminopropyl)phthalonitrile as a precursor, the previously unknown metal‐free 2,9,16,23‐tetra‐(3‐N, N‐diethylaminopropyl)phthalocyanine was prepared and converted to its zinc (II) and its cationic water‐soluble 2,9,16,23‐tetramethylammonium zinc (II) iodide derivatives. Other new phthalocyanine derivatives tested, include a 2,9,16,23‐tetra(2‐hydroxymethyl‐2‐methyIbutoxy)phthalocyaninato zinc (II) and 2,3,9,10,16,17,23,24‐octahydroxyphthalocyaninato zinc (II) derivatives. Boron tribromide cleavage of the newly prepared and fully characterized 2,3,9,10,16,17,23,24‐octamethoxyphthalocyanine gave the unstable metal‐free octahydroxyphthalocy‐anine, which could only be characterized by ultraviolet‐visible, NMR and IR spectroscopy. Copyright © 1989, Wiley Blackwell. All rights reserved
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