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פותח על ידי קלירמאש פתרונות בע"מ -
Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone
Year:
1999
Source of publication :
Cancer Research
Authors :
פינס, מרק
;
.
Volume :
59
Co-Authors:
Elkin, M., Department of Oncology, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel, Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel
Ariel, I., Department of Pathology, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel
Miao, H.-Q., Department of Oncology, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel, Department of Surgical Research, Children's Hospital, Boston, MA 02115, United States
Nagler, A., Department of Bone Marrow Transplant, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel
Pines, M., Institute of Animal Science, Volcany Center, Bet Dagan 50250, Israel
De-Groot, N., Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel
Hochberg, A., Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel
Vlodavsky, I., Department of Oncology, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel, Department of Oncology, Hadassah Hospital, P. O. Box 12000, Jerusalem 91120, Israel
Facilitators :
From page:
4111
To page:
4118
(
Total pages:
8
)
Abstract:
We have previously demonstrated that halofuginone, a widely used alkaloid coccidiostat, is a potent inhibitor of collagen α1(I) and matrix metalloproteinase 2 gene expression. Halofuginone also suppresses extracellular matrix deposition and cell proliferation. We investigated the effect of halofuginone on transplantable and chemically induced mouse bladder carcinoma. In both systems, oral administration of halofuginone resulted in a profound anticancerous effect, even when the treatment was initiated at advanced stages of tumor development. Although halofuginone failed to prevent proliferative preneoplastic alterations in the bladder epithelium, it inhibited further progression of the chemically induced tumor into a malignant invasive stage. Histological examination and in situ analysis of the tumor tissue revealed a marked decrease in blood vessel density and in both collagen α1(I) and H19 gene expression. H19 is regarded as an early marker of bladder carcinoma. The antiangiogenic effect of halofuginone was also demonstrated by inhibition of microvessel formation in vitro. We attribute the profound antitumoral effect of halofuginone to its combined inhibition of the tumor stromal support, vascularization, invasiveness, and cell proliferation.
Note:
Related Files :
animal experiment
animal model
Animals
animal tissue
Cell Proliferation
Male
mice
oral drug administration
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
20373
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:36
Scientific Publication
Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone
59
Elkin, M., Department of Oncology, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel, Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel
Ariel, I., Department of Pathology, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel
Miao, H.-Q., Department of Oncology, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel, Department of Surgical Research, Children's Hospital, Boston, MA 02115, United States
Nagler, A., Department of Bone Marrow Transplant, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel
Pines, M., Institute of Animal Science, Volcany Center, Bet Dagan 50250, Israel
De-Groot, N., Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel
Hochberg, A., Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel
Vlodavsky, I., Department of Oncology, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel, Department of Oncology, Hadassah Hospital, P. O. Box 12000, Jerusalem 91120, Israel
Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone
We have previously demonstrated that halofuginone, a widely used alkaloid coccidiostat, is a potent inhibitor of collagen α1(I) and matrix metalloproteinase 2 gene expression. Halofuginone also suppresses extracellular matrix deposition and cell proliferation. We investigated the effect of halofuginone on transplantable and chemically induced mouse bladder carcinoma. In both systems, oral administration of halofuginone resulted in a profound anticancerous effect, even when the treatment was initiated at advanced stages of tumor development. Although halofuginone failed to prevent proliferative preneoplastic alterations in the bladder epithelium, it inhibited further progression of the chemically induced tumor into a malignant invasive stage. Histological examination and in situ analysis of the tumor tissue revealed a marked decrease in blood vessel density and in both collagen α1(I) and H19 gene expression. H19 is regarded as an early marker of bladder carcinoma. The antiangiogenic effect of halofuginone was also demonstrated by inhibition of microvessel formation in vitro. We attribute the profound antitumoral effect of halofuginone to its combined inhibition of the tumor stromal support, vascularization, invasiveness, and cell proliferation.
Scientific Publication
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