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פותח על ידי קלירמאש פתרונות בע"מ -
A 1-MB PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors
Year:
1999
Source of publication :
genomics (source)
Authors :
סרוסי, אייל
;
.
Volume :
62
Co-Authors:
Yang, Y., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Kiss, H., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Kost-Alimova, M., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Kedra, D., Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden
Fransson, I., Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden
Seroussi, E., Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden
Li, J., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Szeles, A., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Kholodnyuk, I., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Imreh, M.P., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Fodor, K., Biological Research Center, Hungarian Academy of Sciences, H-6001 Szeged, Hungary
Hadlaczky, G., Biological Research Center, Hungarian Academy of Sciences, H-6001 Szeged, Hungary
Klein, G., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Dumanski, J.P., Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden
Imreh, S., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Facilitators :
From page:
147
To page:
155
(
Total pages:
9
)
Abstract:
We have developed an elimination test to identify chromosomal regions that contain tumor inhibitory genes. Monochromosomal human/mouse microcell hybrids are generated and passaged through SCID mice. Derived tumors are then analyzed for deletions on the transgenomic chromosome. Using this strategy, we have previously identified a 1.6-cM common eliminated region 1 (CER1) on human 3p21.3. We now report that CER1 contains 14 markers that are deleted in 19 SCID-derived tumors. A 1-Mb PAC contig that spans CER1 was assembled. Five chemokine receptor genes (CCR1, CCR3, CCR2, CCR5, and CCR6) were localized in CER1 in a 225-kb cluster. The lactotransferrin gene (LTF, or lactoferrin, LF), which reportedly has tumor inhibitory activity, also maps to CER1. Our results create a basis for characterization and further functional testing of genes within CER1.
Note:
Related Files :
animal cell
Animals
gene mapping
Genes
genetic markers
mice
tumor suppressor gene
עוד תגיות
תוכן קשור
More details
DOI :
10.1006/geno.1999.5952
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
20459
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:36
You may also be interested in
Scientific Publication
A 1-MB PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors
62
Yang, Y., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Kiss, H., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Kost-Alimova, M., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Kedra, D., Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden
Fransson, I., Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden
Seroussi, E., Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden
Li, J., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Szeles, A., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Kholodnyuk, I., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Imreh, M.P., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Fodor, K., Biological Research Center, Hungarian Academy of Sciences, H-6001 Szeged, Hungary
Hadlaczky, G., Biological Research Center, Hungarian Academy of Sciences, H-6001 Szeged, Hungary
Klein, G., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Dumanski, J.P., Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden
Imreh, S., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
A 1-MB PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors
We have developed an elimination test to identify chromosomal regions that contain tumor inhibitory genes. Monochromosomal human/mouse microcell hybrids are generated and passaged through SCID mice. Derived tumors are then analyzed for deletions on the transgenomic chromosome. Using this strategy, we have previously identified a 1.6-cM common eliminated region 1 (CER1) on human 3p21.3. We now report that CER1 contains 14 markers that are deleted in 19 SCID-derived tumors. A 1-Mb PAC contig that spans CER1 was assembled. Five chemokine receptor genes (CCR1, CCR3, CCR2, CCR5, and CCR6) were localized in CER1 in a 225-kb cluster. The lactotransferrin gene (LTF, or lactoferrin, LF), which reportedly has tumor inhibitory activity, also maps to CER1. Our results create a basis for characterization and further functional testing of genes within CER1.
Scientific Publication
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