אסיף מאגר המחקר החקלאי

Prevalence of the VNIc genotype of Cryptococcus neoformans in non-HIV-associated cryptococcosis in the Republic of Korea

Year:

2010

Source of publication :

Authors :

Volume :

10

Co-Authors:

Choi, Y.H., Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD 20892, United States, Department of Pulmonary and Critical Care Medicine, Ajou University, School OfMedicine, Suwon, South Korea
Ngamskulrungroj, P., Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD 20892, United States
Varma, A., Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD 20892, United States
Sionov, E., Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD 20892, United States
Hwang, S.M., Department of Clinical Laboratory Science, Catholic University of Pusan, Busan, South Korea
Carriconde, F., Molecular Mycology Research Laboratory, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
Meyer, W., Molecular Mycology Research Laboratory, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
Litvintseva, A.P., Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, United States
Lee, W.G., Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, South Korea
Shin, J.H., Department of Laboratory Medicine, College of Medicine, Chonnam National University, Gwangju, South Korea
Kim, E.-C., Department of Laboratory Medicine, Seoul National University, Seoul, South Korea
Lee, K.W., Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University, Seoul, South Korea
Choi, T.Y., Department of Laboratory Medicine, Hanyang University Hospital, Seoul, South Korea
Lee, Y.S., Center for Infectious Disease, National Institute of Health, Seoul, South Korea
Kwon-Chung, K.J., Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD 20892, United States

Facilitators :

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Abstract:

PCR fingerprinting and multilocus sequence typing were applied to determine the major molecular types of the Cryptococcus neoformansCryptococcus gattii species complex in the Republic of Korea. Of the 78 strains isolated from patients diagnosed with cryptococcosis between 1990 and 2008, 96% were C. neoformans serotype A, mating type MATα and molecular type VNI. The remaining 4% were C. gattii, serotype B, mating type MATα and either molecular type VGIIb or VGIII. Of the 62 strains with known HIV status, only 14 (22.6%) were isolated from HIV-positive patients and belonged to molecular type VNI. Remarkably, 93% of the C. neoformans isolates had identical PCR fingerprint profiles with the VNIc genotype that has been identified recently as the major genotype among C. neoformans strains in China. Most strains (81.8%) of the VNIc genotype were associated with non-HIV patients compared with strains of the non-VNIc genotype (20%) (P=0.009). Unlike the Chinese strains, a majority (60%) of the non-HIV patients infected with strains of the VNIc genotype in the Republic of Korea had serious underlying conditions, with cancer and liver disease being the most common. This study affirms VNIc to be the most prevalent genotype of C. neoformans isolated from non-HIV patients with cryptococcosis.

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