Darvasi, A., Department of Genetics, Hebrew University, Jerusalem, Israel.
Weller, J.I., Department of Genetics, Hebrew University, Jerusalem, Israel.
Weller, J.I., Department of Genetics, Hebrew University, Jerusalem, Israel.
The approximate maximum likelihood method of Luo & Kearsey (1989) to determine the parameters of a segregating quantitative trait locus (QTL) in an F2 population by linkage to a genetic marker is compared to the 'true' maximum likelihood estimates derived by scanning the seven parameter likelihood space. The two methods did not yield identical results, and diverged markedly for a dominant QTL loosely linked to the genetic marker. Further study is suggested to evaluate other methods that do not simultaneously maximize the likelihood for all parameters.
