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פותח על ידי קלירמאש פתרונות בע"מ -
Estimation of quantitative trait locus allele frequency via a modified granddaughter design
Year:
2002
Source of publication :
Genetics (מקור פרסום )
Authors :
ולר, חיים
;
.
ולר, יהודה
;
.
קליגר, דוד
;
.
רון, מיכה
;
.
Volume :
162
Co-Authors:
Weller, J.I., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel, Vol Cani Ctr., P.O. Box 6, Bet Dagan 50250, Israel
Weiler, H., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel, Jerusalem College of Technology, Jerusalem 91160, Israel
Kliger, D., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Ron, M., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
841
To page:
849
(
Total pages:
9
)
Abstract:
A method is described on the basis of a modification of the granddaughter design to obtain estimates of quantitative trait loci (QTL) allele frequencies in dairy cattle populations and to determine QTL genotypes for both homozygous and heterozygous grandsires. The method is based on determining the QTL allele passed from grandsires to their maternal granddaughters using haplotypes consisting of several closely linked genetic markers. This method was applied to simulated data of 10 grandsire families, each with 500 granddaughters, and a QTL with a substitution effect of 0.4 phenotypic standard deviations and to actual data for a previously analyzed QTL in the center of chromosome 6, with substitution effect of 1 phenotypic standard deviation on protein percentage. In the simulated data the standard error for the estimated QTL substitution effect with four closely linked multiallelic markers was only 7% greater than the expected standard error with completely correct identification of QTL allele origin. The method estimated the population QTL allelic frequency as 0.64 ± 0.07, compared to the simulated value of 0.7. In the actual data, the frequency of the allele that increases protein percentage was estimated as 0.63 ± 0.06. In both data sets the hypothesis of equal allelic frequencies was rejected at P < 0.05.
Note:
Related Files :
Animal
Animals
cattle
dairy cattle
gene frequency
genetic linkage
genetic markers
Genetics
Heterozygote
phenotype
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
20513
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:37
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Scientific Publication
Estimation of quantitative trait locus allele frequency via a modified granddaughter design
162
Weller, J.I., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel, Vol Cani Ctr., P.O. Box 6, Bet Dagan 50250, Israel
Weiler, H., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel, Jerusalem College of Technology, Jerusalem 91160, Israel
Kliger, D., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Ron, M., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Estimation of quantitative trait locus allele frequency via a modified granddaughter design
A method is described on the basis of a modification of the granddaughter design to obtain estimates of quantitative trait loci (QTL) allele frequencies in dairy cattle populations and to determine QTL genotypes for both homozygous and heterozygous grandsires. The method is based on determining the QTL allele passed from grandsires to their maternal granddaughters using haplotypes consisting of several closely linked genetic markers. This method was applied to simulated data of 10 grandsire families, each with 500 granddaughters, and a QTL with a substitution effect of 0.4 phenotypic standard deviations and to actual data for a previously analyzed QTL in the center of chromosome 6, with substitution effect of 1 phenotypic standard deviation on protein percentage. In the simulated data the standard error for the estimated QTL substitution effect with four closely linked multiallelic markers was only 7% greater than the expected standard error with completely correct identification of QTL allele origin. The method estimated the population QTL allelic frequency as 0.64 ± 0.07, compared to the simulated value of 0.7. In the actual data, the frequency of the allele that increases protein percentage was estimated as 0.63 ± 0.06. In both data sets the hypothesis of equal allelic frequencies was rejected at P < 0.05.
Scientific Publication
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