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פותח על ידי קלירמאש פתרונות בע"מ -
The Metabolism of Ethylene Dibromide in the Rat I. Identification of Detoxification Products in Urine
Year:
1966
Source of publication :
Israel Journal of Chemistry
Authors :
אלומות (אולומוקי), אוגניה
;
.
נחתומי, עדנה
;
.
Volume :
4
Co-Authors:
Nachtomi, E., National and University Institute of Agriculture, Rehovot, Israel
Alumot, E., National and University Institute of Agriculture, Rehovot, Israel
Bondi, A., National and University Institute of Agriculture, Rehovot, Israel
Facilitators :
From page:
239
To page:
246
(
Total pages:
8
)
Abstract:
The metabolism of ethylene dibromide (EDB) has been studied after administration of this compound to rats by stomach tube. N‐acetyl‐S‐(β‐hydroxyethyl)cysteine was isolated from the urine of EDB‐dosed rats. The identity of this compound with synthetic N‐acetyl‐S‐(β‐ hydroxyethyl)cysteine was proved by chromatographic and electrophoretic methods and by identification of the products obtained by acid and alkaline hydrolysis, by enzymatic hydrolysis and oxidation to a sulfoxide. The second metabolite found in the urine in small amounts was proved to be identical with synthetic S‐(β‐hydroxyethyl)cysteine. The products of hydrolysis and oxidation obtained from the two compounds were shown by chromatography to be the same. The symmetric S‐S'‐ethylene‐bis‐(N‐acetyl) cysteine has not been found in the urine of EDB‐treated rats. When ethylene dichloride or ethylene bromohydrin was administered to rats, the same metabolites were detected in the urine as after EDB poisoning. Copyright © 1966 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Note:
Related Files :
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תוכן קשור
More details
DOI :
10.1002/ijch.196600038
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
20605
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:37
Scientific Publication
The Metabolism of Ethylene Dibromide in the Rat I. Identification of Detoxification Products in Urine
4
Nachtomi, E., National and University Institute of Agriculture, Rehovot, Israel
Alumot, E., National and University Institute of Agriculture, Rehovot, Israel
Bondi, A., National and University Institute of Agriculture, Rehovot, Israel
The Metabolism of Ethylene Dibromide in the Rat I. Identification of Detoxification Products in Urine
The metabolism of ethylene dibromide (EDB) has been studied after administration of this compound to rats by stomach tube. N‐acetyl‐S‐(β‐hydroxyethyl)cysteine was isolated from the urine of EDB‐dosed rats. The identity of this compound with synthetic N‐acetyl‐S‐(β‐ hydroxyethyl)cysteine was proved by chromatographic and electrophoretic methods and by identification of the products obtained by acid and alkaline hydrolysis, by enzymatic hydrolysis and oxidation to a sulfoxide. The second metabolite found in the urine in small amounts was proved to be identical with synthetic S‐(β‐hydroxyethyl)cysteine. The products of hydrolysis and oxidation obtained from the two compounds were shown by chromatography to be the same. The symmetric S‐S'‐ethylene‐bis‐(N‐acetyl) cysteine has not been found in the urine of EDB‐treated rats. When ethylene dichloride or ethylene bromohydrin was administered to rats, the same metabolites were detected in the urine as after EDB poisoning. Copyright © 1966 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Scientific Publication
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