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קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
pH dependence of the phototoxic and photomutagenic effects of chlorpromazine
Year:
1980
Source of publication :
Chemico-Biological Interactions
Authors :
רוזנטל, יונל
;
.
Volume :
29
Co-Authors:
Ben-Hur, E., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
Prager, A., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
Green, M., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
Rosenthal, I., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
Facilitators :
From page:
223
To page:
233
(
Total pages:
11
)
Abstract:
The pH dependence of the phototoxic effects of chloropromazine (CPZ) in Escherichia coli, Salmonella typhimurium and Chinese hamster cells were studied at pH 6-8. All three biological systems displayed higher photosensitization of the drug at lower pH-values. In S. typhimurium the combined action of drug and light also showed mutagenic activity which correlated with toxicity when exposed at pH 7 or 8. When solutions of protein or DNA and CPZ were exposed to near ultraviolet (UV) light, the drug became covalently attached to the macromolecules. This binding was pH dependent but did not correlate with the effects in vivo. It was found however that the permeability of the cells to the drug was enhanced at lower pH-values. It is suggested that the enhanced entrance of CPZ at lower pH-values into the cells facilitated the drug binding to DNA, RNA and proteins within the cells upon light exposure, and that this is the basis for the enhanced phototoxicity and mutagenicity of CPZ. © 1980.
Note:
Related Files :
Animal
animal experiment
DNA
Heredity
mutation
pH
RNA
ultraviolet radiation
Ultraviolet Rays
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/0009-2797(80)90035-6
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
20764
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:38
Scientific Publication
pH dependence of the phototoxic and photomutagenic effects of chlorpromazine
29
Ben-Hur, E., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
Prager, A., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
Green, M., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
Rosenthal, I., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
pH dependence of the phototoxic and photomutagenic effects of chlorpromazine
The pH dependence of the phototoxic effects of chloropromazine (CPZ) in Escherichia coli, Salmonella typhimurium and Chinese hamster cells were studied at pH 6-8. All three biological systems displayed higher photosensitization of the drug at lower pH-values. In S. typhimurium the combined action of drug and light also showed mutagenic activity which correlated with toxicity when exposed at pH 7 or 8. When solutions of protein or DNA and CPZ were exposed to near ultraviolet (UV) light, the drug became covalently attached to the macromolecules. This binding was pH dependent but did not correlate with the effects in vivo. It was found however that the permeability of the cells to the drug was enhanced at lower pH-values. It is suggested that the enhanced entrance of CPZ at lower pH-values into the cells facilitated the drug binding to DNA, RNA and proteins within the cells upon light exposure, and that this is the basis for the enhanced phototoxicity and mutagenicity of CPZ. © 1980.
Scientific Publication
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