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אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Effects of metformin on plasma insulin, glucose metabolism and protein synthesis in the common carp (Cyprinus carpio L.)
Year:
1989
Source of publication :
Aquaculture (source)
Authors :
חפר, בלפור
;
.
Volume :
80
Co-Authors:
Hertz, Y., The Hebrew University of Jerusalem, Department of Biochemistry and Human Nutrition, Rehovot, 76100, Israel
Epstein, N., Israel Institute for Biological Research, Department of Microbiology, Ness-Ziona, 70450, Israel
Abraham, M., Department of Zoology, Jerusalem, 91904, Israel
Madar, Z., The Hebrew University of Jerusalem, Department of Biochemistry and Human Nutrition, Rehovot, 76100, Israel
Hepher, B., Agricultural Research Organization, Fish and Aquaculture Research Station, Israel
Gertler, A., The Hebrew University of Jerusalem, Department of Biochemistry and Human Nutrition, Rehovot, 76100, Israel
Facilitators :
From page:
175
To page:
187
(
Total pages:
13
)
Abstract:
A heterologous radioimmunoassay was developed to measure insulin levels in common carp plasma, using Bonito insulin components. The specificity of the antibodies was demonstrated by using an immunocytochemical technique and by dose-response curves of plasma dilutions from carp which were paralleled to the Bonito insulin standard curve. Plasma insulin levels of fasted carp were 5.4 ng/ml and nearly doubled in fed fish. The incorporation of 3H leucine into white muscle proteins of fed fish doubled as compared to the fasting group. Treatment with metformin increased the disposal of glucose during glucose tolerance tests and the incorporation of 3H leucine into white muscle proteins, inhibited gluconeogenesis from 14C alanine, but had no effect on plasma insulin or basal glucose levels. The mode of action of metformin is probably similar in fish and mammals. © 1989.
Note:
Related Files :
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תוכן קשור
More details
DOI :
10.1016/0044-8486(89)90283-4
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
20853
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:39
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Scientific Publication
Effects of metformin on plasma insulin, glucose metabolism and protein synthesis in the common carp (Cyprinus carpio L.)
80
Hertz, Y., The Hebrew University of Jerusalem, Department of Biochemistry and Human Nutrition, Rehovot, 76100, Israel
Epstein, N., Israel Institute for Biological Research, Department of Microbiology, Ness-Ziona, 70450, Israel
Abraham, M., Department of Zoology, Jerusalem, 91904, Israel
Madar, Z., The Hebrew University of Jerusalem, Department of Biochemistry and Human Nutrition, Rehovot, 76100, Israel
Hepher, B., Agricultural Research Organization, Fish and Aquaculture Research Station, Israel
Gertler, A., The Hebrew University of Jerusalem, Department of Biochemistry and Human Nutrition, Rehovot, 76100, Israel
Effects of metformin on plasma insulin, glucose metabolism and protein synthesis in the common carp (Cyprinus carpio L.)
A heterologous radioimmunoassay was developed to measure insulin levels in common carp plasma, using Bonito insulin components. The specificity of the antibodies was demonstrated by using an immunocytochemical technique and by dose-response curves of plasma dilutions from carp which were paralleled to the Bonito insulin standard curve. Plasma insulin levels of fasted carp were 5.4 ng/ml and nearly doubled in fed fish. The incorporation of 3H leucine into white muscle proteins of fed fish doubled as compared to the fasting group. Treatment with metformin increased the disposal of glucose during glucose tolerance tests and the incorporation of 3H leucine into white muscle proteins, inhibited gluconeogenesis from 14C alanine, but had no effect on plasma insulin or basal glucose levels. The mode of action of metformin is probably similar in fish and mammals. © 1989.
Scientific Publication
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