Co-Authors:
Khan, N.-U.H., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G.B. Marg, Bhavnagar-364 021, Gujarat, India
Pandya, N., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G.B. Marg, Bhavnagar-364 021, Gujarat, India
Prathap, K.J., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G.B. Marg, Bhavnagar-364 021, Gujarat, India
Kureshy, R.I., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G.B. Marg, Bhavnagar-364 021, Gujarat, India
Abdi, S.H.R., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G.B. Marg, Bhavnagar-364 021, Gujarat, India
Mishra, S., Discipline of Marine Biotechnology and Ecology, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G.B. Marg, Bhavnagar-364 021, Gujarat, India
Bajaj, H.C., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G.B. Marg, Bhavnagar-364 021, Gujarat, India
Abstract:
Chiral Schiff base ligands (S)-H 2L and (R)-H 2L and their complexes (S-Ni-L, R-Ni-L, S-Cu-L, R-Cu-L, S-Zn-L and R-Zn-L) were synthesized, characterized and examined for their DNA binding, antioxidant and antibacterial activities. The complexes showed higher binding affinity to calf thymus DNA with binding constant ranging from 2.0 × 10 5 to 4.5 × 10 6 M -1. All the complexes also exhibited remarkable superoxide (56-99%) and hydroxyl scavenging (45-89%) activities as well as antibacterial activities against gram (+) and gram (-) bacteria. However, none of the complexes showed antifungal activity. Conclusively, S enantiomers of the complexes were found to be relatively more efficient for DNA interaction, antioxidant and antibacterial activities than their R enantiomers. This study reveals the possible utilization of chiral Schiff base complexes for pharmaceutical applications. © 2011 Elsevier B.V. All Rights Reserved.
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