נגישות
menu      
חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Effect of antiooxidants on phthalocyanine photosensitization of human erythrocytes
Year:
1993
Authors :
רוזנטל, יונל
;
.
Volume :
1881
Co-Authors:
Ben-Hur, Ehud, New York Blood Cent., New York, NY,, USA
Rosenthal, Ionel, New York Blood Cent., New York, NY,, USA
Facilitators :
From page:
334
To page:
342
(
Total pages:
9
)
Abstract:
Photohemolysis of human erythrocytes sensitized by sulfonated aluminum phthalocyanine was used as an endpoint to study possible chemical modifications of photodynamic therapy. Ascorbate, in concentrations up to 0.1 mM, had a small protective effect. In larger amounts it stimulated the rate of photohemolysis in a concentration dependent manner up to 1 mM, by a factor of 2. Azide and D2O tests indicated some participation of singlet oxygen, although to a lesser extent than in the absence of ascorbate. Kinetic considerations augur for reaction path initiated by an interaction of excited sensitizer-ascorbate, parallel to the singlet oxygen-mediated process. Because of the ubiquitous presence of ascorbate in human tissues in concentrations comparable to those of dissolved oxygen, it is a reasonable estimation that in photodynamic therapy, a fraction of the photodynamic damage proceeds via a Type I, ascorbate-assisted mechanism. Tocopherol had an effect opposite to that of ascorbate, namely it inhibited the photohemolysis. Likewise, quercetin, a plant flavonoid, was protective against phthalocyanine-induced photohemolysis.
Note:
Related Files :
antioxidants
Blood
Drug products
Oncology
Photochemical reactions
Photohemolysis
Photosensitization
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר מתוך כינוס
;
.
Language:
אנגלית
Editors' remarks:
ID:
20912
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:40
You may also be interested in
Scientific Publication
Effect of antiooxidants on phthalocyanine photosensitization of human erythrocytes
1881
Ben-Hur, Ehud, New York Blood Cent., New York, NY,, USA
Rosenthal, Ionel, New York Blood Cent., New York, NY,, USA
Effect of antiooxidants on phthalocyanine photosensitization of human erythrocytes
Photohemolysis of human erythrocytes sensitized by sulfonated aluminum phthalocyanine was used as an endpoint to study possible chemical modifications of photodynamic therapy. Ascorbate, in concentrations up to 0.1 mM, had a small protective effect. In larger amounts it stimulated the rate of photohemolysis in a concentration dependent manner up to 1 mM, by a factor of 2. Azide and D2O tests indicated some participation of singlet oxygen, although to a lesser extent than in the absence of ascorbate. Kinetic considerations augur for reaction path initiated by an interaction of excited sensitizer-ascorbate, parallel to the singlet oxygen-mediated process. Because of the ubiquitous presence of ascorbate in human tissues in concentrations comparable to those of dissolved oxygen, it is a reasonable estimation that in photodynamic therapy, a fraction of the photodynamic damage proceeds via a Type I, ascorbate-assisted mechanism. Tocopherol had an effect opposite to that of ascorbate, namely it inhibited the photohemolysis. Likewise, quercetin, a plant flavonoid, was protective against phthalocyanine-induced photohemolysis.
Scientific Publication
You may also be interested in