On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus

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On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus

Year: 

1992

Source of publication :

Heredity

Authors :

ולר, יהודה

.

Volume :

Co-Authors: 

Darvasi, A., Department of Genetics, The Hebrew University, Jerusalem, 91904, Israel
Weller, J.I., Department of Genetics, The Hebrew University, Jerusalem, 91904, Israel, Institute of Animat Sciences, ARO, The Volcani Center, P.O. Box 6, Bet Dagan, 50250, Israel

From page: 

43

To page: 

46

(

Total pages: 

4

)

Link :

On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus

Abstract: 

The approximate maximum likelihood method of Luo and Kearsey (1989) to determine the parameters of a segregating quantitative trait locus (QTL) in an F2 population by linkage to a genetic marker is compared to the ‘true’ maximum likelihood estimates derived by scanning the seven parameter likelihood space. The two methods did not yield identical results, and diverged markedly for a dominant QTL loosely linked to the genetic marker. Further study is suggested to evaluate other methods that do not simultaneously maximize the likelihood for all parameters. © 1992 The Genetical Society of Great Britain.