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פותח על ידי קלירמאש פתרונות בע"מ -
On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus
Year:
1992
Source of publication :
Heredity
Authors :
ולר, יהודה
;
.
Volume :
68
Co-Authors:
Darvasi, A., Department of Genetics, The Hebrew University, Jerusalem, 91904, Israel
Weller, J.I., Department of Genetics, The Hebrew University, Jerusalem, 91904, Israel, Institute of Animat Sciences, ARO, The Volcani Center, P.O. Box 6, Bet Dagan, 50250, Israel
Facilitators :
From page:
43
To page:
46
(
Total pages:
4
)
Abstract:
The approximate maximum likelihood method of Luo and Kearsey (1989) to determine the parameters of a segregating quantitative trait locus (QTL) in an F2 population by linkage to a genetic marker is compared to the ‘true’ maximum likelihood estimates derived by scanning the seven parameter likelihood space. The two methods did not yield identical results, and diverged markedly for a dominant QTL loosely linked to the genetic marker. Further study is suggested to evaluate other methods that do not simultaneously maximize the likelihood for all parameters. © 1992 The Genetical Society of Great Britain.
Note:
Related Files :
genetic markers
Maximum likelihood
Moments method
Quantitative Trait Loci
עוד תגיות
תוכן קשור
More details
DOI :
10.1038/hdy.1992.5
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
21039
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:41
You may also be interested in
Scientific Publication
On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus
68
Darvasi, A., Department of Genetics, The Hebrew University, Jerusalem, 91904, Israel
Weller, J.I., Department of Genetics, The Hebrew University, Jerusalem, 91904, Israel, Institute of Animat Sciences, ARO, The Volcani Center, P.O. Box 6, Bet Dagan, 50250, Israel
On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus
The approximate maximum likelihood method of Luo and Kearsey (1989) to determine the parameters of a segregating quantitative trait locus (QTL) in an F2 population by linkage to a genetic marker is compared to the ‘true’ maximum likelihood estimates derived by scanning the seven parameter likelihood space. The two methods did not yield identical results, and diverged markedly for a dominant QTL loosely linked to the genetic marker. Further study is suggested to evaluate other methods that do not simultaneously maximize the likelihood for all parameters. © 1992 The Genetical Society of Great Britain.
Scientific Publication
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