חיפוש מתקדם
Heredity
Darvasi, A., Department of Genetics, The Hebrew University, Jerusalem, 91904, Israel
Weller, J.I., Department of Genetics, The Hebrew University, Jerusalem, 91904, Israel, Institute of Animat Sciences, ARO, The Volcani Center, P.O. Box 6, Bet Dagan, 50250, Israel
The approximate maximum likelihood method of Luo and Kearsey (1989) to determine the parameters of a segregating quantitative trait locus (QTL) in an F2 population by linkage to a genetic marker is compared to the ‘true’ maximum likelihood estimates derived by scanning the seven parameter likelihood space. The two methods did not yield identical results, and diverged markedly for a dominant QTL loosely linked to the genetic marker. Further study is suggested to evaluate other methods that do not simultaneously maximize the likelihood for all parameters. © 1992 The Genetical Society of Great Britain.
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הספר "אוצר וולקני"
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תנאי שימוש
On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus
68
Darvasi, A., Department of Genetics, The Hebrew University, Jerusalem, 91904, Israel
Weller, J.I., Department of Genetics, The Hebrew University, Jerusalem, 91904, Israel, Institute of Animat Sciences, ARO, The Volcani Center, P.O. Box 6, Bet Dagan, 50250, Israel
On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus
The approximate maximum likelihood method of Luo and Kearsey (1989) to determine the parameters of a segregating quantitative trait locus (QTL) in an F2 population by linkage to a genetic marker is compared to the ‘true’ maximum likelihood estimates derived by scanning the seven parameter likelihood space. The two methods did not yield identical results, and diverged markedly for a dominant QTL loosely linked to the genetic marker. Further study is suggested to evaluate other methods that do not simultaneously maximize the likelihood for all parameters. © 1992 The Genetical Society of Great Britain.
Scientific Publication
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