Co-Authors:
Yao, F., Department of Microbiology, University of Massachusetts, Amherst, MA 01003, United States
Zhou, H., Department of Microbiology, University of Massachusetts, Amherst, MA 01003, United States
Lessie, T.G., Department of Microbiology, University of Massachusetts, Amherst, MA 01003, United States
Abstract:
Burkholderia multivorans ATCC 17616 ordinarily produces insufficient amounts of N-acyl homoserine lactones (AHLs) to promote AHL-dependent formation of the pigment violacein by the reporter strain Chromobacterium violaceum CV026. We have isolated AHL-overproducing mutants of strain 17616 by screening for variants which do cross-feed AHLs to strain CV026. Nucleotide-sequence analysis of the bmuIR locus which specifies AHL synthase (BmuI) and AHL-binding transcriptional activator protein (BmuR) indicated that the increased capacity to produce AHLs was not a consequence of changes upstream or internal to the bmuI or bmuR genes. We conclude that the mutations leading to AHL overproduction lie outside the bmuI/bmuR locus. © 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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