אסיף מאגר המחקר החקלאי

Effect of hydrocortisone and glucagon on glycogen metabolism in the fetal rat liver

Year:

1975

Source of publication :

Authors :

Volume :

411

Co-Authors:

Pines, M., Pediatric Research Laboratory, Department of Biology, Ben Gurion University of the Negev, Beersheva, Israel
Bashan, N., Pediatric Research Laboratory, Department of Biology, Ben Gurion University of the Negev, Beersheva, Israel
Moses, S.W., Pediatric Research Laboratory, Department of Biology, Ben Gurion University of the Negev, Beersheva, Israel

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Abstract:

1. 1. Hydrocortisone increase in vivo incorporation of [14C]glucose into fetal liver glycogen in the last days of gestation, whereas in glucagon-treated fetuses, a slight decrease in the incorporation rate was found. 2. 2. Hydrocortisone increases total synthetase activity as that of synthetase a but was without effect on fetal liver glycogen phosphorylase. 3. 3. Glucagon causes a slight increase in phosphorylase a activity on days 19-21, and was without effect on the activities of synthetase a and total synthetase. 4. 4. Dibutyryl cyclic AMP had no effect on the key enzymes of glycogen metabolism 1 h after injection in utero, whereas after 6 h an increase in phosphorylase a activity was found without any change in synthetase a activity. © 1975.

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