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פותח על ידי קלירמאש פתרונות בע"מ -
Unique coronary vasodilator induction by leukotriene D4 - (volume 18)
Year:
1985
Authors :
עזרא, דוד
;
.
Volume :
18
Co-Authors:


Feuerstein, G., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Czaja, J.F., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States

Facilitators :
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Total pages:
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Abstract:
Coronary blood flow (CBF) and myocardial contractility decrease markedly in response to intracoronary administration of leukotriene D4 (LTD4). With steady infusion, however, both CBF and contractility escape, approaching preinfusion values despite ongoing LTD4 administration. To clarify the mechanism of this escape, we reinfused plasma from the coronary vein draining the myocardial area receiving LTD4. Introducing this plasma into a coronary artery caused a marked rise in coronary flow for the duration of the plasma infusion. Coronary flow reduction with vasopressin or mechanical occlusion matching that caused by LTD4 failed to elicit vasodilator production. Thus a unique coronary vasodilator factor is induced by LTD4. Whole blood or platelet-rich plasma incubated with LTD4 in vitro produced the same pattern of coronary dilation on intracoronary infusion; LTD4 incubation with platelet-poor plasma failed to elicit a vasodilation. The vasodilator factor is stable and is not potassium, a prostaglandin, catecholamine, histamine, serotonin, adenosine, adenosine diphosphate, or platelet-activating factor. Production of this leukotriene-induced vasodilator factor may account for the escape from LTD4-induced coronary constriction.
Note:
Related Files :
animal experiment
cardiovascular system
coronary artery blood flow
dose response
vasodilatation
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DOI :
Article number:
0
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Database:
סקופוס
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Language:
אנגלית
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ID:
21391
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:43
Scientific Publication
Unique coronary vasodilator induction by leukotriene D4 - (volume 18)
18


Feuerstein, G., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Czaja, J.F., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States

Unique coronary vasodilator induction by leukotriene D4
Coronary blood flow (CBF) and myocardial contractility decrease markedly in response to intracoronary administration of leukotriene D4 (LTD4). With steady infusion, however, both CBF and contractility escape, approaching preinfusion values despite ongoing LTD4 administration. To clarify the mechanism of this escape, we reinfused plasma from the coronary vein draining the myocardial area receiving LTD4. Introducing this plasma into a coronary artery caused a marked rise in coronary flow for the duration of the plasma infusion. Coronary flow reduction with vasopressin or mechanical occlusion matching that caused by LTD4 failed to elicit vasodilator production. Thus a unique coronary vasodilator factor is induced by LTD4. Whole blood or platelet-rich plasma incubated with LTD4 in vitro produced the same pattern of coronary dilation on intracoronary infusion; LTD4 incubation with platelet-poor plasma failed to elicit a vasodilation. The vasodilator factor is stable and is not potassium, a prostaglandin, catecholamine, histamine, serotonin, adenosine, adenosine diphosphate, or platelet-activating factor. Production of this leukotriene-induced vasodilator factor may account for the escape from LTD4-induced coronary constriction.
Scientific Publication
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