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פותח על ידי קלירמאש פתרונות בע"מ -
Stress down regulates milk yield in cows by plasmin induced β-casein product that blocks K+ channels on the apical membranes
Year:
2000
Source of publication :
Life Sciences
Authors :
סילניקוב, ניסים
;
.
שינדר, דמיטרי
;
.
שמאי, אבי
;
.
Volume :
67
Co-Authors:
Silanikove, N., Institute of Animal Science, Agricultural Research Organisation, P.O Box 6, Bet Dagan 50250, Israel
Shamay, A., Institute of Animal Science, Agricultural Research Organisation, P.O Box 6, Bet Dagan 50250, Israel
Shinder, D., Institute of Animal Science, Agricultural Research Organisation, P.O Box 6, Bet Dagan 50250, Israel
Moran, A., Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel
Facilitators :
From page:
2201
To page:
2212
(
Total pages:
12
)
Abstract:
Stress and stress related hormones such as glucocorticoids inhibit lactation in cows. In the present study we propose a novel mechanism connecting stress with plasminogen-plasmin system (PPS) (an enzymatic mechanism-in milk, which leads to the breakdown of the major milk protein casein). We show that stress activates the PPS leading to an increase in plasmin activity, and that a distinct plasmin-induced β-casein breakdown product (fraction 1-28) is a potent blocker of potassium channels in mammary epithelia apical membranes. The reduction in milk production due to dehydration stress or glucocorticoid (dexamethsone) was Correlated with the activities of plasmin and channel blocking activity in the milk of the tested cows. The notion that the axis Stress-PPS-β-casein fraction 1-28 is responsible for the reduction in milk yield is supported by the results of experiments showing that injecting solution composed of casein digest enriched with β-casein fraction 1-28 to the udder lumen leads to a transient reduction in milk production. Furthermore, injecting a pure β-casein fraction 1-28 to the udder lumen of goat's lead also to a transient reduction in milk production with kinetics that was similar to the kinetics observed in cows. (C) 2000 Elsevier Science Inc.
Note:
Related Files :
Animal
animal experiment
beta casein
cattle
Female
goats
lactation
Phosphoserine
stress
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/S0024-3205(00)00808-0
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
21701
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:46
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Scientific Publication
Stress down regulates milk yield in cows by plasmin induced β-casein product that blocks K+ channels on the apical membranes
67
Silanikove, N., Institute of Animal Science, Agricultural Research Organisation, P.O Box 6, Bet Dagan 50250, Israel
Shamay, A., Institute of Animal Science, Agricultural Research Organisation, P.O Box 6, Bet Dagan 50250, Israel
Shinder, D., Institute of Animal Science, Agricultural Research Organisation, P.O Box 6, Bet Dagan 50250, Israel
Moran, A., Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel
Stress down regulates milk yield in cows by plasmin induced β-casein product that blocks K+ channels on the apical membranes
Stress and stress related hormones such as glucocorticoids inhibit lactation in cows. In the present study we propose a novel mechanism connecting stress with plasminogen-plasmin system (PPS) (an enzymatic mechanism-in milk, which leads to the breakdown of the major milk protein casein). We show that stress activates the PPS leading to an increase in plasmin activity, and that a distinct plasmin-induced β-casein breakdown product (fraction 1-28) is a potent blocker of potassium channels in mammary epithelia apical membranes. The reduction in milk production due to dehydration stress or glucocorticoid (dexamethsone) was Correlated with the activities of plasmin and channel blocking activity in the milk of the tested cows. The notion that the axis Stress-PPS-β-casein fraction 1-28 is responsible for the reduction in milk yield is supported by the results of experiments showing that injecting solution composed of casein digest enriched with β-casein fraction 1-28 to the udder lumen leads to a transient reduction in milk production. Furthermore, injecting a pure β-casein fraction 1-28 to the udder lumen of goat's lead also to a transient reduction in milk production with kinetics that was similar to the kinetics observed in cows. (C) 2000 Elsevier Science Inc.
Scientific Publication
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