Co-Authors:
Khan, N.-U.H., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Pandya, N., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Kumar, M., Marine Biology and Ecology Discipline, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Bera, P.K., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Kureshy, R.I., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Abdi, S.H.R., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Bajaj, H.C., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Abstract:
Chiral Mn(iii) salen complexes S-1, R-1, S-2, R-2, S-3 and R-3 derived from the respective chiral salen ligands, viz., (1S,2S)-N,N′-bis-[3-tert- butyl-5-chloromethyl-salicylidine]-1,2-cyclohexanediamine S-1′/(1R,2R)-N, N′-bis-[3-tert-butyl-5-chloromethyl-salicylidine]-1,2-cyclohexanediamine R-1′/(1S,2S)-N,N′-bis-[3-tert-butyl-5-N,N′N′ triethylaminomethyl-salicylidine]-1,2-cyclohexanediamine dichloride S-2′/(1R,2R)-N,N′-bis-[3-tert-butyl-5-N,N′N′ triethylaminomethyl-salicylidine]-1,2-cyclohexanediamine dichloride R-2′/(1S,2S)-N,N′-bis-[3,5-di-tert-butylsalicylidene]-1, 2-cyclohexanediamine S-3′ and (1R,2R)-N,N′-bis-[3,5-di-tert-butyl- salicylidene]-1,2-cyclohexanediamine R-3′, were synthesized. Characterization of the complexes was done by microanalysis, IR, LC-MS, UV-vis. and circular dichroism (CD) spectroscopy. Binding of these complexes with calf thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, circular dichroism measurements, thermal denaturation study and observation of their different antioxidant activities. Among all the complexes used, the best result in terms of binding constant (intercalative) (130.4 × 104) was achieved with the complex S-1 by spectroscopic titration. The complex S-1 showed strong antioxidant activity as well. © 2010 The Royal Society of Chemistry.
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