נגישות
menu      
חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Influence of chirality using Mn(iii) salen complexes on DNA binding and antioxidant activity
Year:
2010
Source of publication :
Organic and Biomolecular Chemistry
Authors :
פנדיה-קומאר, ניראלי
;
.
Volume :
8
Co-Authors:
Khan, N.-U.H., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Pandya, N., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Kumar, M., Marine Biology and Ecology Discipline, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Bera, P.K., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Kureshy, R.I., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Abdi, S.H.R., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Bajaj, H.C., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Facilitators :
From page:
4297
To page:
4307
(
Total pages:
11
)
Abstract:
Chiral Mn(iii) salen complexes S-1, R-1, S-2, R-2, S-3 and R-3 derived from the respective chiral salen ligands, viz., (1S,2S)-N,N′-bis-[3-tert- butyl-5-chloromethyl-salicylidine]-1,2-cyclohexanediamine S-1′/(1R,2R)-N, N′-bis-[3-tert-butyl-5-chloromethyl-salicylidine]-1,2-cyclohexanediamine R-1′/(1S,2S)-N,N′-bis-[3-tert-butyl-5-N,N′N′ triethylaminomethyl-salicylidine]-1,2-cyclohexanediamine dichloride S-2′/(1R,2R)-N,N′-bis-[3-tert-butyl-5-N,N′N′ triethylaminomethyl-salicylidine]-1,2-cyclohexanediamine dichloride R-2′/(1S,2S)-N,N′-bis-[3,5-di-tert-butylsalicylidene]-1, 2-cyclohexanediamine S-3′ and (1R,2R)-N,N′-bis-[3,5-di-tert-butyl- salicylidene]-1,2-cyclohexanediamine R-3′, were synthesized. Characterization of the complexes was done by microanalysis, IR, LC-MS, UV-vis. and circular dichroism (CD) spectroscopy. Binding of these complexes with calf thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, circular dichroism measurements, thermal denaturation study and observation of their different antioxidant activities. Among all the complexes used, the best result in terms of binding constant (intercalative) (130.4 × 104) was achieved with the complex S-1 by spectroscopic titration. The complex S-1 showed strong antioxidant activity as well. © 2010 The Royal Society of Chemistry.
Note:
Related Files :
Animal
Animals
antioxidants
cattle
DNA
free radicals
Genes
metabolism
עוד תגיות
תוכן קשור
More details
DOI :
10.1039/c0ob00010h
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
21784
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:46
You may also be interested in
Scientific Publication
Influence of chirality using Mn(iii) salen complexes on DNA binding and antioxidant activity
8
Khan, N.-U.H., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Pandya, N., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Kumar, M., Marine Biology and Ecology Discipline, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Bera, P.K., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Kureshy, R.I., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Abdi, S.H.R., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Bajaj, H.C., Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021 Gujarat, India
Influence of chirality using Mn(iii) salen complexes on DNA binding and antioxidant activity
Chiral Mn(iii) salen complexes S-1, R-1, S-2, R-2, S-3 and R-3 derived from the respective chiral salen ligands, viz., (1S,2S)-N,N′-bis-[3-tert- butyl-5-chloromethyl-salicylidine]-1,2-cyclohexanediamine S-1′/(1R,2R)-N, N′-bis-[3-tert-butyl-5-chloromethyl-salicylidine]-1,2-cyclohexanediamine R-1′/(1S,2S)-N,N′-bis-[3-tert-butyl-5-N,N′N′ triethylaminomethyl-salicylidine]-1,2-cyclohexanediamine dichloride S-2′/(1R,2R)-N,N′-bis-[3-tert-butyl-5-N,N′N′ triethylaminomethyl-salicylidine]-1,2-cyclohexanediamine dichloride R-2′/(1S,2S)-N,N′-bis-[3,5-di-tert-butylsalicylidene]-1, 2-cyclohexanediamine S-3′ and (1R,2R)-N,N′-bis-[3,5-di-tert-butyl- salicylidene]-1,2-cyclohexanediamine R-3′, were synthesized. Characterization of the complexes was done by microanalysis, IR, LC-MS, UV-vis. and circular dichroism (CD) spectroscopy. Binding of these complexes with calf thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, circular dichroism measurements, thermal denaturation study and observation of their different antioxidant activities. Among all the complexes used, the best result in terms of binding constant (intercalative) (130.4 × 104) was achieved with the complex S-1 by spectroscopic titration. The complex S-1 showed strong antioxidant activity as well. © 2010 The Royal Society of Chemistry.
Scientific Publication
You may also be interested in