אסיף מאגר המחקר החקלאי

Enzymatic resolutions of cyclic amino alcohol precursors

Year:

1989

Source of publication :

Authors :

Volume :

Co-Authors:

Hönig, H., Institute of Organic Chemistry, Graz University of Technology, A-8010 Graz, Austria
Seufer-Wasserthal, P., Institute of Organic Chemistry, Graz University of Technology, A-8010 Graz, Austria
Fülöp, F., Institute of Pharmaceutical Chemistry, University Medical School, Szeged, Hungary

Facilitators :

Link :

Abstract:

Racemic butyrates of trans-2-azido as well as trans-2-nitro and trans-2-cyano cycloalkanols were hydrolysed to the corresponding optically active alcohols with the aid of lipases from Candida cylindracea and Pseudomonas sp. respectively. These precursors of amino alcohols could be produced in optical yields ranging from 85 to >98% e.e. Differences in the catalytic behaviour of the two enzymes depending on ring sizes were observed.

Note:

Related Files :

תוכן קשור

More details

You may also be interested in