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קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Biologic and cytogenetic characteristics of leukemia in infants
Year:
1989
Source of publication :
Cancer
Authors :
קציר, נורית
;
.
Volume :
63
Co-Authors:
Stark, B., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Vogel, R., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Cohen, I.J., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Umiel, T., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Mammon, Z., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Rechavi, G., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Kaplinsky, C., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Potaznik, D., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Dvir, A., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Yaniv, Y., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Goshen, Y., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Katzir, N., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Ramot, B., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Zaizov, R., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Facilitators :
From page:
117
To page:
125
(
Total pages:
9
)
Abstract:
Clinical features, leukemic cell characterization, chromosomal findings, and treatment outcome were analyzed in a retrospective study of 30 cases with acute leukemia of infancy, 24 infants with acute lymphoblastic leukemia (ALL), and six cases with acute nonlymphoblastic leukemia (ANLL). Extensive bulky disease with organomegaly, central nervous system (CNS), and skin involvement were prominent features at diagnosis with a higher frequency in ANLL as compared to ALL. Four of six ANLL patients were classified as monocytic or myelomonocytic. In the ALL group nine of 24 (36%) were non-L1 morphology and six of 17 (33%) were common ALL antigen (CALLA) negative, the majority of them (five of six) were included in the non-L1 group. Immunophenotyping revealed four cases with early B-cell (three patients: Ia+B4+, and one patient: Ia+) and two cases with T-cell. Mixed lineage leukemia was found in five infants. Heavy chain immunoglobulin gene rearrangement was present in six cases tested, two CALLA+, two with Ia+B4+, and two were undifferentiated mixed lineage leukemia. Chromosomal aberrations were detected in ten of 18 patients, mostly in ANLL and CALLA negative ALL. Translocations were detected in six patients, involving 4q21-23 and 11q23 in three and two cases, respectively. The probability of five-year DFS was 27% for the whole group. The worst prognosis was observed in infants younger than 6 months of age, in whom the leukemia cell characteristics was compatible with stem cell: ANLL, very early pre-B, or undifferentiated mixed type. The chromosomal aberrations found in all cases included translocation with the seemingly nonrandom breakpoints at 4q21 and 11q23, and breakpoints included translocation with the seemingly nonrandom breakpoints at 4q21 and 11q23, and breakpoints that corresponded to known fragile sites. This finding may be suggestive of an underlying genetic predisposition associated with the poor prognosis of leukemia of infancy.
Note:
Related Files :
clinical article
Female
Heredity
human cell
Infant
Jews
Leukemia, Nonlymphocytic, Acute
Male
phenotype
Prognosis
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
21954
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:48
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Scientific Publication
Biologic and cytogenetic characteristics of leukemia in infants
63
Stark, B., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Vogel, R., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Cohen, I.J., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Umiel, T., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Mammon, Z., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Rechavi, G., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Kaplinsky, C., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Potaznik, D., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Dvir, A., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Yaniv, Y., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Goshen, Y., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Katzir, N., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Ramot, B., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Zaizov, R., Sambur Center for Pediatric Hematology Oncology, Beilinson Medical Center, 49100 Petach Tikvah, Israel
Biologic and cytogenetic characteristics of leukemia in infants
Clinical features, leukemic cell characterization, chromosomal findings, and treatment outcome were analyzed in a retrospective study of 30 cases with acute leukemia of infancy, 24 infants with acute lymphoblastic leukemia (ALL), and six cases with acute nonlymphoblastic leukemia (ANLL). Extensive bulky disease with organomegaly, central nervous system (CNS), and skin involvement were prominent features at diagnosis with a higher frequency in ANLL as compared to ALL. Four of six ANLL patients were classified as monocytic or myelomonocytic. In the ALL group nine of 24 (36%) were non-L1 morphology and six of 17 (33%) were common ALL antigen (CALLA) negative, the majority of them (five of six) were included in the non-L1 group. Immunophenotyping revealed four cases with early B-cell (three patients: Ia+B4+, and one patient: Ia+) and two cases with T-cell. Mixed lineage leukemia was found in five infants. Heavy chain immunoglobulin gene rearrangement was present in six cases tested, two CALLA+, two with Ia+B4+, and two were undifferentiated mixed lineage leukemia. Chromosomal aberrations were detected in ten of 18 patients, mostly in ANLL and CALLA negative ALL. Translocations were detected in six patients, involving 4q21-23 and 11q23 in three and two cases, respectively. The probability of five-year DFS was 27% for the whole group. The worst prognosis was observed in infants younger than 6 months of age, in whom the leukemia cell characteristics was compatible with stem cell: ANLL, very early pre-B, or undifferentiated mixed type. The chromosomal aberrations found in all cases included translocation with the seemingly nonrandom breakpoints at 4q21 and 11q23, and breakpoints included translocation with the seemingly nonrandom breakpoints at 4q21 and 11q23, and breakpoints that corresponded to known fragile sites. This finding may be suggestive of an underlying genetic predisposition associated with the poor prognosis of leukemia of infancy.
Scientific Publication
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