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Lethal ischemia due to intracoronary endothelin in pigs
Year:
1989
Authors :
עזרא, דוד
;
.
Volume :
257
Co-Authors:
Ezra, D., Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Goldstein, R.E., Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Czaja, J.F., Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Feuerstein, G.Z., Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Facilitators :
From page:
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(
Total pages:
1
)
Abstract:
Endothelin is a recently discovered endothelium-derived peptide with potent coronary constrictor properties in vitro. To evaluate endothelin's cardiac actions in vivo, we measured coronary flow and regional myocardial shortening when intracoronary porcine endothelin was given to anesthetized open-chested pigs. Bolus administration into the left anterior descending (LAD) coronary artery of six pigs caused dose-related rapidly reversing depression of LAD flow and local shortening. Marked reductions in flow [-71 ± 8 (SE) %] and shortening (-83 ± 2%) after 30 pmol/kg demonstrated endothelin's potency in cardiac tissues. Systemic hemocynamic values were unaltered except for transient rises in left ventricular end-diastolic pressure. Endothelin-induced decrement in LAD flow was accompanied by electrocardiographic signs of myocardial ischemia and net release of local myocardial lactate. Intracoronary infusion of endothelin, 15 pmol·kg-1·min-1, caused progressive decline in LAD flow and local shortening followed by severe persistent hypotension and terminal ventricular fibrillation in four of five pigs. Unlike intracoronary delivery of other potent coronary constrictors, intracoronary administration of endothelin did not lead to rapid escape from the peptide's deleterious influence. Coronary exposure to endothelin under pathophysiological circumstances could result in uniquely persistent decrements in myocardial perfusion and contractile function.
Note:
Related Files :
Animal
animal experiment
electrocardiography
Female
lactic acid
Male
peptides
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Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
21984
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:48
Scientific Publication
Lethal ischemia due to intracoronary endothelin in pigs
257
Ezra, D., Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Goldstein, R.E., Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Czaja, J.F., Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Feuerstein, G.Z., Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Lethal ischemia due to intracoronary endothelin in pigs
Endothelin is a recently discovered endothelium-derived peptide with potent coronary constrictor properties in vitro. To evaluate endothelin's cardiac actions in vivo, we measured coronary flow and regional myocardial shortening when intracoronary porcine endothelin was given to anesthetized open-chested pigs. Bolus administration into the left anterior descending (LAD) coronary artery of six pigs caused dose-related rapidly reversing depression of LAD flow and local shortening. Marked reductions in flow [-71 ± 8 (SE) %] and shortening (-83 ± 2%) after 30 pmol/kg demonstrated endothelin's potency in cardiac tissues. Systemic hemocynamic values were unaltered except for transient rises in left ventricular end-diastolic pressure. Endothelin-induced decrement in LAD flow was accompanied by electrocardiographic signs of myocardial ischemia and net release of local myocardial lactate. Intracoronary infusion of endothelin, 15 pmol·kg-1·min-1, caused progressive decline in LAD flow and local shortening followed by severe persistent hypotension and terminal ventricular fibrillation in four of five pigs. Unlike intracoronary delivery of other potent coronary constrictors, intracoronary administration of endothelin did not lead to rapid escape from the peptide's deleterious influence. Coronary exposure to endothelin under pathophysiological circumstances could result in uniquely persistent decrements in myocardial perfusion and contractile function.
Scientific Publication
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