חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells
Year:
2016
Source of publication :
Journal of Functional Foods
Authors :
אלמן, ענת
;
.
ארלנק, הילה
;
.
טלרמן, אלונה
;
.
Volume :
25
Co-Authors:
Elmann, A., Department of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel
Beit-Yannai, E., Clinical Biochemistry and Pharmacology Department, Ben-Gurion University of the Negev, Israel
Telerman, A., Department of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel
Ofir, R., Dead Sea and Arava Science Center, and Department of Immunology and Microbiology, Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Mordechay, S., Department of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel, Faculty of Agriculture, Food and Environmental Quality Sciences of the Hebrew University of Jerusalem, Rehovot, Israel
Erlank, H., Department of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel
Borochov-Neori, H., Southern Arava Research and Development, Hevel Eilot, Israel
Facilitators :
From page:
110
To page:
122
(
Total pages:
13
)
Abstract:
Activated microglial cells release various mediators, which cause neuronal cell death and have been implicated in different neurological disorders. The present study demonstrates that an infusion prepared from the plant Pulicaria incisa (Pi) inhibits microglial activation and down-regulates levels of the inflammatory cytokines interleukin (IL)-1β, IL-6, and of the toxic mediators nitric oxide and glutamate. The infusion was also shown to have antioxidant properties in cell-free assays (e.g., differential pulse voltammetry) and in a cellular assay, in which the infusion attenuated the induced accumulation of intracellular reactive oxygen species (ROS). We found that Pi infusion is rich in polyphenols, especially chlorogenic acids and ferulic acids, which might be responsible for the observed activities. It is proposed that Pi infusion be further evaluated for use as a functional beverage for the prevention and/or treatment of chronic diseases, especially neurodegenerative disorders in which microglial activation and oxidative stress play important roles. © 2016 Elsevier Ltd.
Note:
Related Files :
Glutamate
Herbal infusion
microglial cells
Neuroinflammation
Polyphenols
Pulicaria incisa
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/j.jff.2016.05.012
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
22014
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:48
Scientific Publication
Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells
25
Elmann, A., Department of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel
Beit-Yannai, E., Clinical Biochemistry and Pharmacology Department, Ben-Gurion University of the Negev, Israel
Telerman, A., Department of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel
Ofir, R., Dead Sea and Arava Science Center, and Department of Immunology and Microbiology, Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Mordechay, S., Department of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel, Faculty of Agriculture, Food and Environmental Quality Sciences of the Hebrew University of Jerusalem, Rehovot, Israel
Erlank, H., Department of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel
Borochov-Neori, H., Southern Arava Research and Development, Hevel Eilot, Israel
Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells
Activated microglial cells release various mediators, which cause neuronal cell death and have been implicated in different neurological disorders. The present study demonstrates that an infusion prepared from the plant Pulicaria incisa (Pi) inhibits microglial activation and down-regulates levels of the inflammatory cytokines interleukin (IL)-1β, IL-6, and of the toxic mediators nitric oxide and glutamate. The infusion was also shown to have antioxidant properties in cell-free assays (e.g., differential pulse voltammetry) and in a cellular assay, in which the infusion attenuated the induced accumulation of intracellular reactive oxygen species (ROS). We found that Pi infusion is rich in polyphenols, especially chlorogenic acids and ferulic acids, which might be responsible for the observed activities. It is proposed that Pi infusion be further evaluated for use as a functional beverage for the prevention and/or treatment of chronic diseases, especially neurodegenerative disorders in which microglial activation and oxidative stress play important roles. © 2016 Elsevier Ltd.
Scientific Publication
נגישות
menu      
You may also be interested in