Release of clotting factors from photosensitized endothelial cells: A possible trigger for blood vessel occlusion by photodynamic therapy

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Release of clotting factors from photosensitized endothelial cells: A possible trigger for blood vessel occlusion by photodynamic therapy

Year: 

1988

Source of publication :

FEBS Letters

Authors :

רוזנטל, יונל

.

Volume :

236

Co-Authors: 

Ben-Hur, E., Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel
Heldman, E., Israel Institute for Biological Research, PO Box 19, Nes-Ziona, Israel
Crane, S.W., North Carolina State University, School of Veterinary Medicine, Raleigh, NC 27606, United States
Rosenthal, I., ARO, The Volcani Center, PO Box 6, Bet-Dagan, Israel

From page: 

105

To page: 

108

(

Total pages: 

4

)

Link :

Release of clotting factors from photosensitized endothelial cells: A possible trigger for blood vessel occlusion by photodynamic therapy

Abstract: 

Photodynamic treatment of solid tumors results in the occlusion of blood vessels in the treated tissue. We hypothesize that this process is triggered by the release of one or more clotting factors from the photodamaged endothelial cells. Experimental evidence is presented that immediately after photodynamic treatment, cultured endothelial cells start releasing clotting factors into the medium in a dose range of minimal cytotoxicity. © 1988.