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פותח על ידי קלירמאש פתרונות בע"מ -
Protective effects of the essential oil of Salvia fruticosa and its constituents on astrocytic susceptibility to hydrogen peroxide-induced cell death
Year:
2009
Authors :
אלמן, ענת
;
.
אלקבץ, מיטל
;
.
לרקוב, אולגה
;
.
מרדכי, שרון
;
.
רביד, עוזי
;
.
רינדנר, מרים
;
.
Volume :
57
Co-Authors:
Elmann, A., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel, Food Science Department Agricultural Research Organization, Volcani Center, PO Box 6, Bet Pagan, 50250, Israel
Mordechay, S., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Rindner, M., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Larkov, O., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Elkabetz, M., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Ravid, U., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Facilitators :
From page:
6636
To page:
6641
(
Total pages:
6
)
Abstract:
Oxidative stress has been implicated in pathologic processes associated with neurodegenerative diseases. Astrocytes, the most abundant glial cell type in the brain, protect neurons from reactive oxygen species (ROS), and any damage to them will affect neuronal survival. This study compares the ability of essential oils prepared from different herbs and spices to protect cultured primary brain astrocytes from H2O2-induced death. The results show that the essential oil of Salvia fruticosa (Sf) among the tested essential oils demonstrated remarkable protective activity. The protective effect of Sf could be attributed to a-humulene and a-pinene. Following incubation, α-humulene and trans-ßcaryophyllene could be found in the cytosol of astrocytes. It is proposed that Sf, by attenuating H2O2-induced cell death, might be used as a functional food or may be offered as a means of therapy in the treatment of neurodegenerative diseases. ©2009 American Chemical Society.
Note:
Related Files :
Animal
Animals
drug effect
essential oils
neurodegenerative diseases
Oils, Volatile
Salvia
Salvia fruticosa
עוד תגיות
תוכן קשור
More details
DOI :
10.1021/jf901162f
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
22090
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:49
You may also be interested in
Scientific Publication
Protective effects of the essential oil of Salvia fruticosa and its constituents on astrocytic susceptibility to hydrogen peroxide-induced cell death
57
Elmann, A., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel, Food Science Department Agricultural Research Organization, Volcani Center, PO Box 6, Bet Pagan, 50250, Israel
Mordechay, S., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Rindner, M., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Larkov, O., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Elkabetz, M., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Ravid, U., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Protective effects of the essential oil of Salvia fruticosa and its constituents on astrocytic susceptibility to hydrogen peroxide-induced cell death
Oxidative stress has been implicated in pathologic processes associated with neurodegenerative diseases. Astrocytes, the most abundant glial cell type in the brain, protect neurons from reactive oxygen species (ROS), and any damage to them will affect neuronal survival. This study compares the ability of essential oils prepared from different herbs and spices to protect cultured primary brain astrocytes from H2O2-induced death. The results show that the essential oil of Salvia fruticosa (Sf) among the tested essential oils demonstrated remarkable protective activity. The protective effect of Sf could be attributed to a-humulene and a-pinene. Following incubation, α-humulene and trans-ßcaryophyllene could be found in the cytosol of astrocytes. It is proposed that Sf, by attenuating H2O2-induced cell death, might be used as a functional food or may be offered as a means of therapy in the treatment of neurodegenerative diseases. ©2009 American Chemical Society.
Scientific Publication
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