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חיפוש מתקדם
Elmann, A., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel, Food Science Department Agricultural Research Organization, Volcani Center, PO Box 6, Bet Pagan, 50250, Israel
Mordechay, S., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Rindner, M., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Larkov, O., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Elkabetz, M., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Ravid, U., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Oxidative stress has been implicated in pathologic processes associated with neurodegenerative diseases. Astrocytes, the most abundant glial cell type in the brain, protect neurons from reactive oxygen species (ROS), and any damage to them will affect neuronal survival. This study compares the ability of essential oils prepared from different herbs and spices to protect cultured primary brain astrocytes from H2O2-induced death. The results show that the essential oil of Salvia fruticosa (Sf) among the tested essential oils demonstrated remarkable protective activity. The protective effect of Sf could be attributed to a-humulene and a-pinene. Following incubation, α-humulene and trans-ßcaryophyllene could be found in the cytosol of astrocytes. It is proposed that Sf, by attenuating H2O2-induced cell death, might be used as a functional food or may be offered as a means of therapy in the treatment of neurodegenerative diseases. ©2009 American Chemical Society.
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תנאי שימוש
Protective effects of the essential oil of Salvia fruticosa and its constituents on astrocytic susceptibility to hydrogen peroxide-induced cell death
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Elmann, A., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel, Food Science Department Agricultural Research Organization, Volcani Center, PO Box 6, Bet Pagan, 50250, Israel
Mordechay, S., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Rindner, M., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Larkov, O., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Elkabetz, M., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Ravid, U., Department of Aromatic Plants, Agricultural Research Organization, Ramat Yishay, Israel
Protective effects of the essential oil of Salvia fruticosa and its constituents on astrocytic susceptibility to hydrogen peroxide-induced cell death
Oxidative stress has been implicated in pathologic processes associated with neurodegenerative diseases. Astrocytes, the most abundant glial cell type in the brain, protect neurons from reactive oxygen species (ROS), and any damage to them will affect neuronal survival. This study compares the ability of essential oils prepared from different herbs and spices to protect cultured primary brain astrocytes from H2O2-induced death. The results show that the essential oil of Salvia fruticosa (Sf) among the tested essential oils demonstrated remarkable protective activity. The protective effect of Sf could be attributed to a-humulene and a-pinene. Following incubation, α-humulene and trans-ßcaryophyllene could be found in the cytosol of astrocytes. It is proposed that Sf, by attenuating H2O2-induced cell death, might be used as a functional food or may be offered as a means of therapy in the treatment of neurodegenerative diseases. ©2009 American Chemical Society.
Scientific Publication
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