חיפוש מתקדם
Journal of Insect Physiology
Oberlander, H., Center for Medical, Agric. Vet. Entomol., Agric. Res. S., Gainesville, FL 32604, United States
Leach, C.E., Center for Medical, Agric. Vet. Entomol., Agric. Res. S., Gainesville, FL 32604, United States
Shaaya, E., Agricultural Research Organization, The Volcani Center, 50250, Bet Dagan, Israel
The action of juvenile hormone (JH) and JH mimics have been examined in vitro by utilizing the imaginal disc-derived cell line, IAL-PID2. We have discovered that the cell line was responsive to JH and a variety of JH mimics. The most consistent response obtained in our studies was inhibition of cell proliferation, in the absence of 20-hydroxyecdysone (20E), which characteristically reduces cell proliferation in its own right in this cell line. JH-I, JH-III, methoprene, fenoxycarb, and farnesol significantly inhibited cell proliferation after 3 days of exposure of the cells in vitro to each of the compounds. Linoleic acid controls had no effect on proliferation in the cultures. The cell proliferation assay demonstrates the JH responsiveness of this cell line, but the concentrations of JH required were high compared to the concentrations of 20E needed for inhibition of proliferation in these cells.
פותח על ידי קלירמאש פתרונות בע"מ -
הספר "אוצר וולקני"
אודות
תנאי שימוש
Juvenile hormone and juvenile hormone mimics inhibit proliferation in a lepidopteran imaginal disc cell line
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Oberlander, H., Center for Medical, Agric. Vet. Entomol., Agric. Res. S., Gainesville, FL 32604, United States
Leach, C.E., Center for Medical, Agric. Vet. Entomol., Agric. Res. S., Gainesville, FL 32604, United States
Shaaya, E., Agricultural Research Organization, The Volcani Center, 50250, Bet Dagan, Israel
Juvenile hormone and juvenile hormone mimics inhibit proliferation in a lepidopteran imaginal disc cell line
The action of juvenile hormone (JH) and JH mimics have been examined in vitro by utilizing the imaginal disc-derived cell line, IAL-PID2. We have discovered that the cell line was responsive to JH and a variety of JH mimics. The most consistent response obtained in our studies was inhibition of cell proliferation, in the absence of 20-hydroxyecdysone (20E), which characteristically reduces cell proliferation in its own right in this cell line. JH-I, JH-III, methoprene, fenoxycarb, and farnesol significantly inhibited cell proliferation after 3 days of exposure of the cells in vitro to each of the compounds. Linoleic acid controls had no effect on proliferation in the cultures. The cell proliferation assay demonstrates the JH responsiveness of this cell line, but the concentrations of JH required were high compared to the concentrations of 20E needed for inhibition of proliferation in these cells.
Scientific Publication
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