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פותח על ידי קלירמאש פתרונות בע"מ -
'Retroposon' insertion into the cellular oncogene c-myc in canine transmissible venereal tumor
Year:
1985
Authors :
קציר, נורית
;
.
Volume :
82
Co-Authors:
Katzir, N., Department of Chemical Immunology, The Weizmann Institute, Rehovoth, Israel
Rechavi, G., Department of Chemical Immunology, The Weizmann Institute, Rehovoth, Israel
Cohen, J.B., Department of Chemical Immunology, The Weizmann Institute, Rehovoth, Israel
Unger, T.
Simoni, F.
Segal, S.
Givol, D.
Facilitators :
From page:
1054
To page:
1058
(
Total pages:
5
)
Abstract:
We examined by Southern blotting the state of the cellular oncogene c-myc in the dog transmissible venereal tumor. The tumor DNA contains a 16.8-kilobase pair (kbp) rearranged c-myc fragment in addition to the normal 15-kbp and 7.5-kbp fragments. We compared the structure of the cloned rearranged c-myc (rc-myc) with that of a cloned normal c-myc and found that the rearrangement was due to the insertion of a 1.8-kbp DNA upstream to the first exon of c-myc. The inserted DNA is flanked by 10-base-pair direct repeats and contains a dA-rich tail, suggesting its origin from mRNA. Partial sequence of the inserted element showed 62% homology with the primate interdispersed Kpn I repetitive element. These results provide an example for the behavior of repetitive DNA sequences like the Kpn I family, as movable elements that can transpose nearby to oncogenes or other structural genes and perhaps affect their activity.
Note:
Related Files :
Animals
chromosome mapping
Dog Diseases
genetic engineering
Heredity
Oncogene
עוד תגיות
תוכן קשור
More details
DOI :
10.1073/pnas.82.4.1054
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
22124
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:49
Scientific Publication
'Retroposon' insertion into the cellular oncogene c-myc in canine transmissible venereal tumor
82
Katzir, N., Department of Chemical Immunology, The Weizmann Institute, Rehovoth, Israel
Rechavi, G., Department of Chemical Immunology, The Weizmann Institute, Rehovoth, Israel
Cohen, J.B., Department of Chemical Immunology, The Weizmann Institute, Rehovoth, Israel
Unger, T.
Simoni, F.
Segal, S.
Givol, D.
'Retroposon' insertion into the cellular oncogene c-myc in canine transmissible venereal tumor
We examined by Southern blotting the state of the cellular oncogene c-myc in the dog transmissible venereal tumor. The tumor DNA contains a 16.8-kilobase pair (kbp) rearranged c-myc fragment in addition to the normal 15-kbp and 7.5-kbp fragments. We compared the structure of the cloned rearranged c-myc (rc-myc) with that of a cloned normal c-myc and found that the rearrangement was due to the insertion of a 1.8-kbp DNA upstream to the first exon of c-myc. The inserted DNA is flanked by 10-base-pair direct repeats and contains a dA-rich tail, suggesting its origin from mRNA. Partial sequence of the inserted element showed 62% homology with the primate interdispersed Kpn I repetitive element. These results provide an example for the behavior of repetitive DNA sequences like the Kpn I family, as movable elements that can transpose nearby to oncogenes or other structural genes and perhaps affect their activity.
Scientific Publication
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