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פותח על ידי קלירמאש פתרונות בע"מ -
Parameter estimation for ligand binding systems kinetics applied to 1,25-dihydroxycholecalciferol
Year:
1986
Source of publication :
Analytical Biochemistry
Authors :
בר, אריה
;
.
הורויץ, שמואל (בעלי חיים)
;
.
טלפז, חובב
;
.
פישמן, ס'
;
.
Volume :
154
Co-Authors:
Fishman, S., Department of Statistics and Experiment Design, The Volcani Center, Post Office Box 6, Bet Dagan, 50250, Israel
Talpaz, H., Department of Statistics and Experiment Design, The Volcani Center, Post Office Box 6, Bet Dagan, 50250, Israel
Bar, A., Institute of Animal Sciences, Agricultural Research Organization, The Volcani Center, Post Office Box 6, Bet Dagan, 50250, Israel
Hurwitz, S., Institute of Animal Sciences, Agricultural Research Organization, The Volcani Center, Post Office Box 6, Bet Dagan, 50250, Israel
Facilitators :
From page:
144
To page:
151
(
Total pages:
8
)
Abstract:
A mathematical analysis of the kinetics of the hormone-receptor interaction was applied to the 1,25-dihydroxycholecalciferol-intestinal receptor system. The exact analytical solution and the numerical integration of the kinetic equation were installed in a Statistical Analysis System (SAS) computer program to estimate the rate constants of the reaction. Estimates of the parameters obtained by these two methods are similar, demonstrating that the numerical integration can be combined with the nonlinear regression procedure for least-squares parameter fitting using a simple SAS program. This enables estimation of kinetics rate constants when the kinetic equation cannot be solved analytically. The ratio of the rate constants ( ka kd) found by the nonlinear procedure is close to the independently determined equilibrium (Scatchard) constant in the nonlinear analysis. © 1986.
Note:
Related Files :
Animal
Binding
calcitriol
Kinetics
mathematical model
Models, Biological
pharmacokinetics
Receptor
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/0003-2697(86)90508-7
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
22314
Last updated date:
21/08/2022 07:45
Creation date:
16/04/2018 23:50
Scientific Publication
Parameter estimation for ligand binding systems kinetics applied to 1,25-dihydroxycholecalciferol
154
Fishman, S., Department of Statistics and Experiment Design, The Volcani Center, Post Office Box 6, Bet Dagan, 50250, Israel
Talpaz, H., Department of Statistics and Experiment Design, The Volcani Center, Post Office Box 6, Bet Dagan, 50250, Israel
Bar, A., Institute of Animal Sciences, Agricultural Research Organization, The Volcani Center, Post Office Box 6, Bet Dagan, 50250, Israel
Hurwitz, S., Institute of Animal Sciences, Agricultural Research Organization, The Volcani Center, Post Office Box 6, Bet Dagan, 50250, Israel
Parameter estimation for ligand binding systems kinetics applied to 1,25-dihydroxycholecalciferol
A mathematical analysis of the kinetics of the hormone-receptor interaction was applied to the 1,25-dihydroxycholecalciferol-intestinal receptor system. The exact analytical solution and the numerical integration of the kinetic equation were installed in a Statistical Analysis System (SAS) computer program to estimate the rate constants of the reaction. Estimates of the parameters obtained by these two methods are similar, demonstrating that the numerical integration can be combined with the nonlinear regression procedure for least-squares parameter fitting using a simple SAS program. This enables estimation of kinetics rate constants when the kinetic equation cannot be solved analytically. The ratio of the rate constants ( ka kd) found by the nonlinear procedure is close to the independently determined equilibrium (Scatchard) constant in the nonlinear analysis. © 1986.
Scientific Publication
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