אסיף מאגר המחקר החקלאי

Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model

Year:

2015

Source of publication :

Authors :

Volume :

16

Co-Authors:

Mayzlish-Gati, E., Institute of Plant Sciences, ARO, Volcani Center, Bet Dagan, Israel
Laufer, D., Institute of Plant Sciences, ARO, Volcani Center, Bet Dagan, Israel, The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Grivas, C.F., Department of Human Science, SNHS, Georgetown University, Washington, DC, United States
Shaknof, J., Institute of Plant Sciences, ARO, Volcani Center, Bet Dagan, Israel
Sananes, A., Institute of Plant Sciences, ARO, Volcani Center, Bet Dagan, Israel, The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Bier, A., Institute of Plant Sciences, ARO, Volcani Center, Bet Dagan, Israel
Ben-Harosh, S., The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Belausov, E., Institute of Plant Sciences, ARO, Volcani Center, Bet Dagan, Israel
Johnson, M.D., Department of Oncology, Georgetown University Medical Center, Washington, DC, United States, The Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States
Artuso, E., Department of Chemistry, University of Turin, Torino, Italy
Levi, O., Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Genin, O., Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Prandi, C., Department of Chemistry, University of Turin, Torino, Italy
Khalaila, I., The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Pines, M., Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Yarden, R.I., Department of Human Science, SNHS, Georgetown University, Washington, DC, United States, The Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States
Kapulnik, Y., Institute of Plant Sciences, ARO, Volcani Center, Bet Dagan, Israel
Koltai, H., Institute of Plant Sciences, ARO, Volcani Center, Bet Dagan, Israel

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Abstract:

Strigolactones (SLs) are a novel class of plant hormones. Previously, we found that analogs of SLs induce growth arrest and apoptosis in breast cancer cell lines. These compounds also inhibited the growth of breast cancer stem cell enriched-mammospheres with increased potency. Furthermore, strigolactone analogs inhibited growth and survival of colon, lung, prostate, melanoma, osteosarcoma and leukemia cancer cell lines. To further examine the anti-cancer activity of SLs in vivo, we have examined their effects on growth and viability of MDA-MB-231 tumor xenografts model either alone or in combination with paclitaxel. We show that strigolactone act as new anti-cancer agents in inhibition of breast cancer in xenograft model. In addition we show that SLs affect the integrity of the microtubule network and therefore may inhibit the migratory phenotype of the highly invasive breast cancer cell lines that were examined. © 2015 Taylor & Francis Group, LLC.

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