נגישות
menu      
חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis
Year:
2007
Source of publication :
Molecular Systems Biology
Authors :
גנאים, מוראד
;
.
Volume :
3
Co-Authors:
Hooper, S.D., Structural and Computational Biology Unit, EMBL, Heidelberg, Germany
Boué, S., Structural and Computational Biology Unit, EMBL, Heidelberg, Germany
Krause, R., Department Vingron, Max-Planck-Institute for Molecular Genetics, Berlin, Germany, Department Zychlinsky, Max-Planck-Institute for Infection Biology, Berlin, Germany
Jensen, L.J., Structural and Computational Biology Unit, EMBL, Heidelberg, Germany
Mason, C.E., Department of Genetics, Yale University, School of Medicine, New Haven, CT, United States
Ghanim, M., Department of Genetics, Yale University, School of Medicine, New Haven, CT, United States
White, K.P., Department of Genetics, Yale University, School of Medicine, New Haven, CT, United States
Furlong, E.E.M., Structural and Computational Biology Unit, EMBL, Heidelberg, Germany, Gene Expression Unit, EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Bork, P., Structural and Computational Biology Unit, EMBL, Heidelberg, Germany, Structural and Computational Biology Unit, EMBL, Meyerhofstrasse 1, Heidelberg 69117, Germany
Facilitators :
From page:
To page:
(
Total pages:
1
)
Abstract:
Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. By applying conservative filtering criteria and requiring 'sharp' transcript changes, we identified 1534 maternal genes, 792 transient zygotic genes, and 1053 genes whose transcript levels increase during embryogenesis. Each of these three categories is dominated by groups of genes where all transcript levels increase and/or decrease at similar times, suggesting a common mode of regulation. For example, 34% of the transiently expressed genes fall into three groups, with increased transcript levels between 2.5-12, 11-20, and 15-20 h of development, respectively. We highlight common and distinctive functional features of these expression groups and identify a coupling between downregulation of transcript levels and targeted protein degradation. By mapping the groups to the protein network, we also predict and experimentally confirm new functional associations. © 2007 EMBO and Nature Publishing Group All rights reserved.
Note:
Related Files :
Animal
Animals
Drosophila protein
gene expression
Genetics
metabolism
Receptors, Notch
unclassified drug
עוד תגיות
תוכן קשור
More details
DOI :
10.1038/msb4100112
Article number:
72
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
22488
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:52
You may also be interested in
Scientific Publication
Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis
3
Hooper, S.D., Structural and Computational Biology Unit, EMBL, Heidelberg, Germany
Boué, S., Structural and Computational Biology Unit, EMBL, Heidelberg, Germany
Krause, R., Department Vingron, Max-Planck-Institute for Molecular Genetics, Berlin, Germany, Department Zychlinsky, Max-Planck-Institute for Infection Biology, Berlin, Germany
Jensen, L.J., Structural and Computational Biology Unit, EMBL, Heidelberg, Germany
Mason, C.E., Department of Genetics, Yale University, School of Medicine, New Haven, CT, United States
Ghanim, M., Department of Genetics, Yale University, School of Medicine, New Haven, CT, United States
White, K.P., Department of Genetics, Yale University, School of Medicine, New Haven, CT, United States
Furlong, E.E.M., Structural and Computational Biology Unit, EMBL, Heidelberg, Germany, Gene Expression Unit, EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Bork, P., Structural and Computational Biology Unit, EMBL, Heidelberg, Germany, Structural and Computational Biology Unit, EMBL, Meyerhofstrasse 1, Heidelberg 69117, Germany
Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis
Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. By applying conservative filtering criteria and requiring 'sharp' transcript changes, we identified 1534 maternal genes, 792 transient zygotic genes, and 1053 genes whose transcript levels increase during embryogenesis. Each of these three categories is dominated by groups of genes where all transcript levels increase and/or decrease at similar times, suggesting a common mode of regulation. For example, 34% of the transiently expressed genes fall into three groups, with increased transcript levels between 2.5-12, 11-20, and 15-20 h of development, respectively. We highlight common and distinctive functional features of these expression groups and identify a coupling between downregulation of transcript levels and targeted protein degradation. By mapping the groups to the protein network, we also predict and experimentally confirm new functional associations. © 2007 EMBO and Nature Publishing Group All rights reserved.
Scientific Publication
You may also be interested in