Co-Authors:
Borisover, M.D., Inst. Soil, Water and Environ. Sci., Volcani Center, ARO 50250 Bet Dagan, Israel
Zakharychev, D.V., Department of Chemistry, Kazan State University, 420008, Kazan, Russian Federation
Solomonov, B.N., Department of Chemistry, Kazan State University, 420008, Kazan, Russian Federation
Abstract:
Human serum albumin (HSA) immersed in pyridine-n-hexane mixtures was analyzed using differential scanning calorimetry (DSC). State of the solid HSA in organic solvent mixtures is the non-equilibrium state which is seen as the exothermic peak on the DSC curves. The enthalpy change corresponding to this exothermic peak approaches zero when going from pure pyridine to pure n-hexane. Dependence of the enthalpy change on the pyridine concentration is suggestive that the non-equilibrium state of the immersed HSA results from the HSA-pyridine interactions 'frozen' at the lower temperature. Most likely the temperature-initiated exothermic peak observed on the DSC curves reflects the swelling of HSA by pyridine.
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