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קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Fibrosis inhibition and muscle histopathology improvement in laminin-α2-deficient mice
Year:
2010
Source of publication :
Muscle and Nerve
Authors :
גנין, אולגה
;
.
הראל ,מיכל
;
.
משה, איתי
;
.
פינס, מרק
;
.
Volume :
42
Co-Authors:
Nevo, Y., Neuropediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Halevy, O., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot, Israel
Genin, O., Institute of Animal Sciences, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Moshe, I., Institute of Animal Sciences, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Turgeman, T., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot, Israel, Institute of Animal Sciences, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Harel, M., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot, Israel, Institute of Animal Sciences, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Biton, E., Neuropediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel, Department of Pediatrics and Pediatric Gastroenterology Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Israel
Reif, S., Department of Pediatrics and Pediatric Gastroenterology Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Israel
Pines, M., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot, Israel
Facilitators :
From page:
218
To page:
229
(
Total pages:
12
)
Abstract:
In muscular dystrophies (MD) the loss of muscle and its ability to function are associated with fibrosis. We evaluated the efficacy of halofuginone in reducing fibrosis in the dy2J/dy2J mouse model of congenital MD. Mice were injected intraperitoneally with 5 μg of halofuginone 3 times a week for 5 or 15 weeks, starting at the age of 3 weeks. Halofuginone caused a reduction in collagen synthesis in hindlimb muscles. This was associated with reductions in the degenerated area, in cell proliferation, in the number of myofibers with central nuclei, with increased myofiber diameter, and with enhanced motor coordination and balance. Halofuginone caused a reduction in infiltrating fibroblasts that were located close to centrally nucleated myofibers. Our results suggest that halofuginone reduced the deleterious effects of fibrosis, thus improving muscle integrity. Halofuginone meets the criteria for a novel antifibrotic therapy for MD patients. © 2010 Wiley Periodicals, Inc.
Note:
Related Files :
animal experiment
animal model
Animals
animal tissue
Cell Proliferation
hindlimb
mice
motor coordination
Muscular dystrophy
עוד תגיות
תוכן קשור
More details
DOI :
10.1002/mus.21706
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
22659
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:53
You may also be interested in
Scientific Publication
Fibrosis inhibition and muscle histopathology improvement in laminin-α2-deficient mice
42
Nevo, Y., Neuropediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Halevy, O., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot, Israel
Genin, O., Institute of Animal Sciences, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Moshe, I., Institute of Animal Sciences, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Turgeman, T., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot, Israel, Institute of Animal Sciences, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Harel, M., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot, Israel, Institute of Animal Sciences, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Biton, E., Neuropediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel, Department of Pediatrics and Pediatric Gastroenterology Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Israel
Reif, S., Department of Pediatrics and Pediatric Gastroenterology Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Israel
Pines, M., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot, Israel
Fibrosis inhibition and muscle histopathology improvement in laminin-α2-deficient mice
In muscular dystrophies (MD) the loss of muscle and its ability to function are associated with fibrosis. We evaluated the efficacy of halofuginone in reducing fibrosis in the dy2J/dy2J mouse model of congenital MD. Mice were injected intraperitoneally with 5 μg of halofuginone 3 times a week for 5 or 15 weeks, starting at the age of 3 weeks. Halofuginone caused a reduction in collagen synthesis in hindlimb muscles. This was associated with reductions in the degenerated area, in cell proliferation, in the number of myofibers with central nuclei, with increased myofiber diameter, and with enhanced motor coordination and balance. Halofuginone caused a reduction in infiltrating fibroblasts that were located close to centrally nucleated myofibers. Our results suggest that halofuginone reduced the deleterious effects of fibrosis, thus improving muscle integrity. Halofuginone meets the criteria for a novel antifibrotic therapy for MD patients. © 2010 Wiley Periodicals, Inc.
Scientific Publication
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