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פותח על ידי קלירמאש פתרונות בע"מ -
A maize defense-inducible gene is a major facilitator superfamily member related to bacterial multidrug resistance efflux antiporters
Year:
2003
Source of publication :
Plant Molecular Biology
Authors :
נברו, שלמה
;
.
פרידלנדר, מרסלו
;
.
Volume :
52
Co-Authors:
Simmons, C.R., Bioinformatics Department, Pioneer Hi-Bred International, Inc., 7300 N.W. 62nd Avenue, Johnston, IA 50131-1004, United States
Fridlender, M., Science Park Rehovot, Box 4018, 5 Oppenheimer Street, Nes Ziona, 70400, Israel
Navarro, P.A., Bioinformatics Department, Pioneer Hi-Bred International, Inc., 7300 N.W. 62nd Avenue, Johnston, IA 50131-1004, United States
Yalpani, N., Disease Resistance Department, Pioneer Hi-Bred International, Inc., 7300 N.W. 62nd Avenue, Johnston, IA 50131-1004, United States
Facilitators :
From page:
433
To page:
446
(
Total pages:
14
)
Abstract:
A defense-inducible maize gene was discovered through global mRNA profiling analysis. Its mRNA expression is induced by pathogens and defense-related conditions in various tissues involving both resistant and susceptible interactions. These include Cochliobolus heterostrophus and Cochliobolus carbonum infection, ultraviolet light treatment, the Les9 disease lesion mimic background, and plant tissues engineered to express flavonoids or the avirulence gene avrRxv. The gene was named Zm-mfs1 after it was found to encode a protein related to the major facilitator superfamily (MFS) of intregral membrane permeases. It is most closely related to the bacterial multidrug efflux protein family, typified by the Escherichia coli TetA, which are proton motive force antiporters that export antimicrobial drugs and other compounds, but which can be also involved in potassium export/proton import or potassium re-uptake. Other related plant gene sequences in maize, rice, and Arabidopsis were identified, three of which are introduced here. Among this new plant MFS subfamily, the characteristic MFS motif in cytoplasmic TM2-TM3 loop, and the antiporter family motif in transmembrane domain TM5 are both conserved, however the TM7 and the cytoplasmic TM8-TM9 loop are divergent from those of the bacterial multidrug transporters. We hypothesize that Zm-Mfs1 is a prototype of a new class of plant defense-related proteins that could be involved in either of three nonexclusive roles: (1) export of antimicrobial compounds produced by plant pathogens; (2) export of plant-generated antimicrobial compounds; and (3) potassium export and/or re-uptake, as can occur in plant defense reactions.
Note:
Related Files :
arabidopsis
flavonoids
genetic engineering
Molecular Biology
proteins
RNA
tissue culture
Zea mays
עוד תגיות
תוכן קשור
More details
DOI :
10.1023/A:1023982704901
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
22692
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:53
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Scientific Publication
A maize defense-inducible gene is a major facilitator superfamily member related to bacterial multidrug resistance efflux antiporters
52
Simmons, C.R., Bioinformatics Department, Pioneer Hi-Bred International, Inc., 7300 N.W. 62nd Avenue, Johnston, IA 50131-1004, United States
Fridlender, M., Science Park Rehovot, Box 4018, 5 Oppenheimer Street, Nes Ziona, 70400, Israel
Navarro, P.A., Bioinformatics Department, Pioneer Hi-Bred International, Inc., 7300 N.W. 62nd Avenue, Johnston, IA 50131-1004, United States
Yalpani, N., Disease Resistance Department, Pioneer Hi-Bred International, Inc., 7300 N.W. 62nd Avenue, Johnston, IA 50131-1004, United States
A maize defense-inducible gene is a major facilitator superfamily member related to bacterial multidrug resistance efflux antiporters
A defense-inducible maize gene was discovered through global mRNA profiling analysis. Its mRNA expression is induced by pathogens and defense-related conditions in various tissues involving both resistant and susceptible interactions. These include Cochliobolus heterostrophus and Cochliobolus carbonum infection, ultraviolet light treatment, the Les9 disease lesion mimic background, and plant tissues engineered to express flavonoids or the avirulence gene avrRxv. The gene was named Zm-mfs1 after it was found to encode a protein related to the major facilitator superfamily (MFS) of intregral membrane permeases. It is most closely related to the bacterial multidrug efflux protein family, typified by the Escherichia coli TetA, which are proton motive force antiporters that export antimicrobial drugs and other compounds, but which can be also involved in potassium export/proton import or potassium re-uptake. Other related plant gene sequences in maize, rice, and Arabidopsis were identified, three of which are introduced here. Among this new plant MFS subfamily, the characteristic MFS motif in cytoplasmic TM2-TM3 loop, and the antiporter family motif in transmembrane domain TM5 are both conserved, however the TM7 and the cytoplasmic TM8-TM9 loop are divergent from those of the bacterial multidrug transporters. We hypothesize that Zm-Mfs1 is a prototype of a new class of plant defense-related proteins that could be involved in either of three nonexclusive roles: (1) export of antimicrobial compounds produced by plant pathogens; (2) export of plant-generated antimicrobial compounds; and (3) potassium export and/or re-uptake, as can occur in plant defense reactions.
Scientific Publication
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