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Barash, I., Department of Virology, The Wiezmann Institute of Science 76100 Rehovot, Israel
Fishelson, Z., Department of Virology, The Wiezmann Institute of Science 76100 Rehovot, Israel
Revel, M., Department of Virology, The Wiezmann Institute of Science 76100 Rehovot, Israel
Human skin fibroblasts sythesize and secrete complement Factor B, a component of the complement alternative pathway, when stimulated by mediators of inflammation such as lipopolysaccharide and various cytokines. Recombinant IL-6/IFN-β2 (E. coli) stimulates Factor B synthesis in fibroblasts but the effect is strongly potentiated by the addition of IFN-γ. When both cytokines are added, the skin fibroblasts secrete significant amounts of biologically active Factor B detectabel in a hemolysis test. This cooperative effect of IL-6, which is made by most tissue cells and monocytes and of IFN-γ which is made by T-lymphocytes may play a role in local inflammatory processes. IL-6 and IFN-γ also cooperate in the induction of (2'-5') A synthetase, a mediator of IFN action.
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תנאי שימוש
Induction of complement factor B activity in human fibroblasts by IL-6/IFN-β2 and IFN-γ
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Barash, I., Department of Virology, The Wiezmann Institute of Science 76100 Rehovot, Israel
Fishelson, Z., Department of Virology, The Wiezmann Institute of Science 76100 Rehovot, Israel
Revel, M., Department of Virology, The Wiezmann Institute of Science 76100 Rehovot, Israel
Induction of complement factor B activity in human fibroblasts by IL-6/IFN-β2 and IFN-γ
Human skin fibroblasts sythesize and secrete complement Factor B, a component of the complement alternative pathway, when stimulated by mediators of inflammation such as lipopolysaccharide and various cytokines. Recombinant IL-6/IFN-β2 (E. coli) stimulates Factor B synthesis in fibroblasts but the effect is strongly potentiated by the addition of IFN-γ. When both cytokines are added, the skin fibroblasts secrete significant amounts of biologically active Factor B detectabel in a hemolysis test. This cooperative effect of IL-6, which is made by most tissue cells and monocytes and of IFN-γ which is made by T-lymphocytes may play a role in local inflammatory processes. IL-6 and IFN-γ also cooperate in the induction of (2'-5') A synthetase, a mediator of IFN action.
Scientific Publication
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