חיפוש מתקדם
FEBS Letters
Regev, A., Entomology Department, Institute of Plant Protection, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel, Department of Plant Sciences, George S. Wise Fac. of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978 Tel-Aviv, Israel
Rivkin, H., Entomology Department, Institute of Plant Protection, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Inceoglu, B., Department of Entomology, University of California, Davis, CA 95616, United States
Gershburg, E., Entomology Department, Institute of Plant Protection, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel, Department of Plant Sciences, George S. Wise Fac. of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978 Tel-Aviv, Israel
Hammock, B.D., Department of Entomology, University of California, Davis, CA 95616, United States
Gurevitz, M., Department of Plant Sciences, George S. Wise Fac. of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978 Tel-Aviv, Israel
Chejanovsky, N., Entomology Department, Institute of Plant Protection, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
We have studied whether the cooperative insecticidal effect of certain scorpion toxin pairs, namely either a combination of excitatory and depressant, or alpha and depressant scorpion toxins, would improve the efficacy of Autographa californica nucleopolyhedrovirus (AcMNPV) over a virus expressing only a single toxin, towards Heliothis virescens, Helicoverpa armigera, and Spodoptera littoralis larvae. The best result was achieved by combined expression of the excitatory toxin, LqhIT1, and the depressant toxin, LqhIT2, that provided an ET50 value of 46.9 h on H. virescens neonates, an improvement of 40% over the efficacy of wild-type AcMNPV, and of 18% and 22% over baculoviruses that express each of the toxins independently. These results demonstrate that significant improvement in efficacy of recombinant baculoviruses is obtainable with toxins that exhibit a cooperative effect, and may contribute to employ baculoviruses to replace hazardous chemicals in insect control. © 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
פותח על ידי קלירמאש פתרונות בע"מ -
הספר "אוצר וולקני"
אודות
תנאי שימוש
Further enhancement of baculovirus insecticidal efficacy with scorpion toxins that interact cooperatively
537
Regev, A., Entomology Department, Institute of Plant Protection, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel, Department of Plant Sciences, George S. Wise Fac. of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978 Tel-Aviv, Israel
Rivkin, H., Entomology Department, Institute of Plant Protection, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Inceoglu, B., Department of Entomology, University of California, Davis, CA 95616, United States
Gershburg, E., Entomology Department, Institute of Plant Protection, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel, Department of Plant Sciences, George S. Wise Fac. of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978 Tel-Aviv, Israel
Hammock, B.D., Department of Entomology, University of California, Davis, CA 95616, United States
Gurevitz, M., Department of Plant Sciences, George S. Wise Fac. of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978 Tel-Aviv, Israel
Chejanovsky, N., Entomology Department, Institute of Plant Protection, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Further enhancement of baculovirus insecticidal efficacy with scorpion toxins that interact cooperatively
We have studied whether the cooperative insecticidal effect of certain scorpion toxin pairs, namely either a combination of excitatory and depressant, or alpha and depressant scorpion toxins, would improve the efficacy of Autographa californica nucleopolyhedrovirus (AcMNPV) over a virus expressing only a single toxin, towards Heliothis virescens, Helicoverpa armigera, and Spodoptera littoralis larvae. The best result was achieved by combined expression of the excitatory toxin, LqhIT1, and the depressant toxin, LqhIT2, that provided an ET50 value of 46.9 h on H. virescens neonates, an improvement of 40% over the efficacy of wild-type AcMNPV, and of 18% and 22% over baculoviruses that express each of the toxins independently. These results demonstrate that significant improvement in efficacy of recombinant baculoviruses is obtainable with toxins that exhibit a cooperative effect, and may contribute to employ baculoviruses to replace hazardous chemicals in insect control. © 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Scientific Publication
You may also be interested in