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פותח על ידי קלירמאש פתרונות בע"מ -
Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
Year:
2006
Source of publication :
Genome Biology
Authors :
פרייליך, שירי
;
.
Volume :
7
Co-Authors:
Freilich, S., EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SB, United Kingdom
Massingham, T., EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SB, United Kingdom
Blanc, E., EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SB, United Kingdom
Goldovsky, L., EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SB, United Kingdom
Thornton, J.M., EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SB, United Kingdom
Facilitators :
From page:
To page:
(
Total pages:
1
)
Abstract:
Background: Gene duplications have been hypothesized to be a major factor in enabling the evolution of tissue differentiation. Analyses of the expression profiles of duplicate genes in mammalian tissues have indicated that, with time, the expression patterns of duplicate genes diverge and become more tissue specific. We explored the relationship between duplication events, the time at which they took place, and both the expression breadth of the duplicated genes and the cumulative expression breadth of the gene family to which they belong. Results: We show that only duplicates that arose through post-multicellularity duplication events show a tendency to become more specifically expressed, whereas such a tendency is not observed for duplicates that arose in a unicellular ancestor. Unlike the narrow expression profile of the duplicated genes, the overall expression of gene families tends to maintain a global expression pattern. Conclusion: The work presented here supports the view suggested by the subfunctionalization model, namely that expression divergence in different tissues, following gene duplication, promotes the retention of a gene in the genome of multicellular species. The global expression profile of the gene families suggests division of expression between family members, whose expression becomes specialized. Because specialization of expression is coupled with an increased rate of sequence divergence, it can facilitate the evolution of new, tissue-specific functions. © 2006 Freilich et al.; licensee BioMed Central Ltd.
Note:
Related Files :
Animal
Animals
gene expression
Genetics
Mammalia
mice
Molecular Evolution
proteins
עוד תגיות
תוכן קשור
More details
DOI :
10.1186/gb-2006-7-10-r89
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
23012
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:56
Scientific Publication
Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
7
Freilich, S., EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SB, United Kingdom
Massingham, T., EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SB, United Kingdom
Blanc, E., EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SB, United Kingdom
Goldovsky, L., EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SB, United Kingdom
Thornton, J.M., EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SB, United Kingdom
Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
Background: Gene duplications have been hypothesized to be a major factor in enabling the evolution of tissue differentiation. Analyses of the expression profiles of duplicate genes in mammalian tissues have indicated that, with time, the expression patterns of duplicate genes diverge and become more tissue specific. We explored the relationship between duplication events, the time at which they took place, and both the expression breadth of the duplicated genes and the cumulative expression breadth of the gene family to which they belong. Results: We show that only duplicates that arose through post-multicellularity duplication events show a tendency to become more specifically expressed, whereas such a tendency is not observed for duplicates that arose in a unicellular ancestor. Unlike the narrow expression profile of the duplicated genes, the overall expression of gene families tends to maintain a global expression pattern. Conclusion: The work presented here supports the view suggested by the subfunctionalization model, namely that expression divergence in different tissues, following gene duplication, promotes the retention of a gene in the genome of multicellular species. The global expression profile of the gene families suggests division of expression between family members, whose expression becomes specialized. Because specialization of expression is coupled with an increased rate of sequence divergence, it can facilitate the evolution of new, tissue-specific functions. © 2006 Freilich et al.; licensee BioMed Central Ltd.
Scientific Publication
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