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פותח על ידי קלירמאש פתרונות בע"מ -
Spontaneous inactivation of enkephalin
Year:
1978
Authors :
אלטשטיין, מרים
;
.
Volume :
85
Co-Authors:
Vogel, Z., Department of Neurobiology, The Weizmann Institute of Science Rehovot, Israel
Miron, T., Department of Biophysics, The Weizmann Institute of Science Rehovot, Israel
Altstein, M., Department of Neurobiology, The Weizmann Institute of Science Rehovot, Israel
Wilchek, M., Department of Biophysics, The Weizmann Institute of Science Rehovot, Israel
Facilitators :
From page:
226
To page:
233
(
Total pages:
8
)
Abstract:
Dilute solutions of enkephalin are not stable upon prolonged storage. A new peak of UV absorption (at 325 nm) gradually appears. This change in spectral properties is accompanied by an alteration in the chromatographic pattern as well as the spontaneous modification of the tyrosyl residue of the enkephalin molecule. The A325 nm peak suggests that the tyrosine residue is converted into an indole derivative. The new material is biologically inactive as indicated by its failure to interact with opiate receptors or with antibodies against native enkephalin. In addition the modified peptide is not hydrolyzed by brain extracts or leucine aminopeptidase. This spontaneous inactivation of enkephalin should be taken into account, particularly in experiments utilizing dilute solutions of enkephalin. © 1978 Academic Press, Inc.
Note:
Related Files :
Animal
brain
cell membrane
drug solution
Drug Stability
drug storage
Kinetics
Male
Receptors, Opioid
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/S0006-291X(78)80033-3
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
23029
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:56
Scientific Publication
Spontaneous inactivation of enkephalin
85
Vogel, Z., Department of Neurobiology, The Weizmann Institute of Science Rehovot, Israel
Miron, T., Department of Biophysics, The Weizmann Institute of Science Rehovot, Israel
Altstein, M., Department of Neurobiology, The Weizmann Institute of Science Rehovot, Israel
Wilchek, M., Department of Biophysics, The Weizmann Institute of Science Rehovot, Israel
Spontaneous inactivation of enkephalin
Dilute solutions of enkephalin are not stable upon prolonged storage. A new peak of UV absorption (at 325 nm) gradually appears. This change in spectral properties is accompanied by an alteration in the chromatographic pattern as well as the spontaneous modification of the tyrosyl residue of the enkephalin molecule. The A325 nm peak suggests that the tyrosine residue is converted into an indole derivative. The new material is biologically inactive as indicated by its failure to interact with opiate receptors or with antibodies against native enkephalin. In addition the modified peptide is not hydrolyzed by brain extracts or leucine aminopeptidase. This spontaneous inactivation of enkephalin should be taken into account, particularly in experiments utilizing dilute solutions of enkephalin. © 1978 Academic Press, Inc.
Scientific Publication
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