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אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Evidence for an extrarenal action of chlorothiazide on serum potassium
Year:
1982
Source of publication :
Mineral and Electrolyte Metabolism
Authors :
עזרא, דוד
;
.
Volume :
7
Co-Authors:
Ezra, D., Heller Inst. Med. Res., Chaim Sheba Med. Cent., 52621 Tel-Hashomer, Israel
Iaina, A., Heller Inst. Med. Res., Chaim Sheba Med. Cent., 52621 Tel-Hashomer, Israel
Kapuler, S., Heller Inst. Med. Res., Chaim Sheba Med. Cent., 52621 Tel-Hashomer, Israel
Almog, S.
Eshkol, A.
Gavendo, S.
Eliahou, H.E.
Gafni, J.
Facilitators :
From page:
285
To page:
291
(
Total pages:
7
)
Abstract:
The effects of chlorothiazide and furosemide on serum potassium were studied in 9 fasting anuric patients maintained by chronic hemodialysis and compared to a control period when no drug was administered. Serum potassium levels were significantly lower following oral chlorothiazide (15 mg/kg body weight) than during the control period. After intravenous furosemide (1 mg/kg body weight), potassium levels were midway between those of the chlorothiazide and control periods, but statistical significance was not attained. Comparing the three study periods, there were no significant differences in the changes in body weight, blood pressure, blood pH, hematocit, urea, glucose, sodium, albumin, insulin, plasma renin activity and aldosterone. This suggests that an extrarenal action of chlorothiazide on the cell membrane promotes cellular uptake of potassium.
Note:
Related Files :
Aldosterone
cell membrane
furosemide
hemodialysis
hemodialysis fluid
intravenous drug administration
Kidney
therapy
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
23131
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:57
Scientific Publication
Evidence for an extrarenal action of chlorothiazide on serum potassium
7
Ezra, D., Heller Inst. Med. Res., Chaim Sheba Med. Cent., 52621 Tel-Hashomer, Israel
Iaina, A., Heller Inst. Med. Res., Chaim Sheba Med. Cent., 52621 Tel-Hashomer, Israel
Kapuler, S., Heller Inst. Med. Res., Chaim Sheba Med. Cent., 52621 Tel-Hashomer, Israel
Almog, S.
Eshkol, A.
Gavendo, S.
Eliahou, H.E.
Gafni, J.
Evidence for an extrarenal action of chlorothiazide on serum potassium
The effects of chlorothiazide and furosemide on serum potassium were studied in 9 fasting anuric patients maintained by chronic hemodialysis and compared to a control period when no drug was administered. Serum potassium levels were significantly lower following oral chlorothiazide (15 mg/kg body weight) than during the control period. After intravenous furosemide (1 mg/kg body weight), potassium levels were midway between those of the chlorothiazide and control periods, but statistical significance was not attained. Comparing the three study periods, there were no significant differences in the changes in body weight, blood pressure, blood pH, hematocit, urea, glucose, sodium, albumin, insulin, plasma renin activity and aldosterone. This suggests that an extrarenal action of chlorothiazide on the cell membrane promotes cellular uptake of potassium.
Scientific Publication
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