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פותח על ידי קלירמאש פתרונות בע"מ -
Pharmacokinetics of endobronchial tolazoline administration in dogs
Year:
1999
Source of publication :
American Journal of Perinatology
Authors :
עזרא, דוד
;
.
Volume :
16
Co-Authors:
Paret, G., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel, Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Eyal, O., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel
Mayan, H., Division of Clinical Pharmacology, Chaim Sheba Medical Center, Tel Hashomer, Israel
Ben-Abraham, R., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel
Vardi, A., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel
Manisterski, Y., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel
Barzilay, Z., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel
Ezra, D., Division of Clinical Pharmacology, Chaim Sheba Medical Center, Tel Hashomer, Israel
Facilitators :
From page:
1
To page:
6
(
Total pages:
6
)
Abstract:
Tolazoline is a potent vasodilator of arteries and veins and has a powerful effect on the pulmonary vasculature, reducing hypoxic pulmonary vasoconstriction and lowering pulmonary artery pressure. Intravenous tolazoline lowers the mean pulmonary arterial pressure and resistance and increases the cardiac index when given to infants with persistent pulmonary hypertension (PPHN). Endotracheally administered tolazoline decreases mean pulmonary arterial pressure and pulmonary vascular resistance, and improves oxygenation without the harmful decline in the systemic arterial pressure. The purpose of our study was to examine the pharmacokinetic and pharmacodynamic characteristics of endobronchial tolazoline to determine the relationship between endobronchial tolazoline administration, plasma concentration, and its effects on the cardiovascular and respiratory systems. Tolazoline was administered endobronchially to seven dogs, and its serum concentration and the hemodynamic parameters were monitored for 270 min postdelivery. It was found that 15 sec after dosing, tolazoline plasma concentrations started to increase significantly above baseline levels, reaching a maximum of 9.3 ± 8.0 μg · ml-1. The volume of distribution was 1657 ± 321 mL · kg-1 after 12.4 ± 16.6 min. The extent of tolazoline absorption was 319 ± 38 μg · min-1 mL-1. The total body clearance was 10.9 ± 4.8 mL · min-1 · Kg-1 and the elimination half-life was 156 ± 81 min. Endobronchial tolazoline produced an initial short-lived decrease in the mean blood pressure in all the dogs, but thereafter the blood pressure increased gradually above baseline levels. Immediately following endobronchial tolazoline a significant tachycardia developed, peaking at 90 min. Subsequently, the heart rate gradually decreased and stabilized at values above baseline for 200 min. We conclude that an endobronchial bolus dose of tolazoline is effectively absorbed, produces measurable pharmacological effects, and may be beneficial in the therapy of persistent pulmonary hypertension of the newborn.
Note:
Related Files :
Animal
animal model
Animals
drug effect
Female
heart rate
Male
sensitivity and specificity
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תוכן קשור
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DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
23179
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:57
Scientific Publication
Pharmacokinetics of endobronchial tolazoline administration in dogs
16
Paret, G., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel, Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Eyal, O., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel
Mayan, H., Division of Clinical Pharmacology, Chaim Sheba Medical Center, Tel Hashomer, Israel
Ben-Abraham, R., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel
Vardi, A., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel
Manisterski, Y., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel
Barzilay, Z., Dept. of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel
Ezra, D., Division of Clinical Pharmacology, Chaim Sheba Medical Center, Tel Hashomer, Israel
Pharmacokinetics of endobronchial tolazoline administration in dogs
Tolazoline is a potent vasodilator of arteries and veins and has a powerful effect on the pulmonary vasculature, reducing hypoxic pulmonary vasoconstriction and lowering pulmonary artery pressure. Intravenous tolazoline lowers the mean pulmonary arterial pressure and resistance and increases the cardiac index when given to infants with persistent pulmonary hypertension (PPHN). Endotracheally administered tolazoline decreases mean pulmonary arterial pressure and pulmonary vascular resistance, and improves oxygenation without the harmful decline in the systemic arterial pressure. The purpose of our study was to examine the pharmacokinetic and pharmacodynamic characteristics of endobronchial tolazoline to determine the relationship between endobronchial tolazoline administration, plasma concentration, and its effects on the cardiovascular and respiratory systems. Tolazoline was administered endobronchially to seven dogs, and its serum concentration and the hemodynamic parameters were monitored for 270 min postdelivery. It was found that 15 sec after dosing, tolazoline plasma concentrations started to increase significantly above baseline levels, reaching a maximum of 9.3 ± 8.0 μg · ml-1. The volume of distribution was 1657 ± 321 mL · kg-1 after 12.4 ± 16.6 min. The extent of tolazoline absorption was 319 ± 38 μg · min-1 mL-1. The total body clearance was 10.9 ± 4.8 mL · min-1 · Kg-1 and the elimination half-life was 156 ± 81 min. Endobronchial tolazoline produced an initial short-lived decrease in the mean blood pressure in all the dogs, but thereafter the blood pressure increased gradually above baseline levels. Immediately following endobronchial tolazoline a significant tachycardia developed, peaking at 90 min. Subsequently, the heart rate gradually decreased and stabilized at values above baseline for 200 min. We conclude that an endobronchial bolus dose of tolazoline is effectively absorbed, produces measurable pharmacological effects, and may be beneficial in the therapy of persistent pulmonary hypertension of the newborn.
Scientific Publication
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