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Journal of Functional Foods
Orgil, O., Migal Galilee Technology Center, P.O. Box 831, Kiryat Shmona, Israel, Tel Hai College, Upper Galilee, Israel
Spector, L., Migal Galilee Technology Center, P.O. Box 831, Kiryat Shmona, Israel
Holland, D., Institute of Plant Sciences, Agricultural Research Organization, Newe Ya'ar Research Center, Ramat Yishay, Israel
Mahajna, J., Migal Galilee Technology Center, P.O. Box 831, Kiryat Shmona, Israel, Tel Hai College, Upper Galilee, Israel
Amir, R., Migal Galilee Technology Center, P.O. Box 831, Kiryat Shmona, Israel, Tel Hai College, Upper Galilee, Israel
This study monitored the anti-proliferative activity of pomegranate (Punica granatum L.) peel homogenates against breast (MCF7 and MDA-MB-453) and prostate (LNCaP and PC-3) cancer cell lines using 29 different accessions to study the natural diversity in these accessions. Using MTT method, it was revealed that high anti-proliferative activity was observed against MCF7, MDA-MB-453 and LNCaP (androgen-dependent) cell lines for most accessions, while the androgen-independent prostate cancer cell line, PC-3, exhibited relatively high resistance. Peel extracts displayed the highest LNCaP inhibition activity compared to aril juice and seed homogenates. Eight accessions exhibiting the highest anti-proliferative activity were studied further using the LNCaP and PC-3 cancer cells. IC50 and clonogenicity inhibition were determined. Several accessions were found to inhibit androgen receptor activity but not NF-κB transcription function. This study illustrated the importance of exploiting natural pomegranate variation to identify accessions exhibiting potential selective activity for the treatment of specific types of cancer. © 2016 Elsevier Ltd
פותח על ידי קלירמאש פתרונות בע"מ -
הספר "אוצר וולקני"
אודות
תנאי שימוש
The anti-proliferative and anti-androgenic activity of different pomegranate accessions
26
Orgil, O., Migal Galilee Technology Center, P.O. Box 831, Kiryat Shmona, Israel, Tel Hai College, Upper Galilee, Israel
Spector, L., Migal Galilee Technology Center, P.O. Box 831, Kiryat Shmona, Israel
Holland, D., Institute of Plant Sciences, Agricultural Research Organization, Newe Ya'ar Research Center, Ramat Yishay, Israel
Mahajna, J., Migal Galilee Technology Center, P.O. Box 831, Kiryat Shmona, Israel, Tel Hai College, Upper Galilee, Israel
Amir, R., Migal Galilee Technology Center, P.O. Box 831, Kiryat Shmona, Israel, Tel Hai College, Upper Galilee, Israel
The anti-proliferative and anti-androgenic activity of different pomegranate accessions
This study monitored the anti-proliferative activity of pomegranate (Punica granatum L.) peel homogenates against breast (MCF7 and MDA-MB-453) and prostate (LNCaP and PC-3) cancer cell lines using 29 different accessions to study the natural diversity in these accessions. Using MTT method, it was revealed that high anti-proliferative activity was observed against MCF7, MDA-MB-453 and LNCaP (androgen-dependent) cell lines for most accessions, while the androgen-independent prostate cancer cell line, PC-3, exhibited relatively high resistance. Peel extracts displayed the highest LNCaP inhibition activity compared to aril juice and seed homogenates. Eight accessions exhibiting the highest anti-proliferative activity were studied further using the LNCaP and PC-3 cancer cells. IC50 and clonogenicity inhibition were determined. Several accessions were found to inhibit androgen receptor activity but not NF-κB transcription function. This study illustrated the importance of exploiting natural pomegranate variation to identify accessions exhibiting potential selective activity for the treatment of specific types of cancer. © 2016 Elsevier Ltd
Scientific Publication
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