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פותח על ידי קלירמאש פתרונות בע"מ -
Natural compounds derived from foods modulate nitric oxide production and oxidative status in epithelial lung cells
Year:
2005
Authors :
ולר, יהודה
;
.
Volume :
53
Co-Authors:
Zaslaver, M., Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Offer, S., Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Kerem, Z., Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Stark, A.H., Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Weller, J.I., Department of Quantitative and Molecular Genetics, Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Israel
Eliraz, A., Pulmonary Unit, Kaplan Hospital, Rehovot, Israel
Madar, Z., Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Facilitators :
From page:
9934
To page:
9939
(
Total pages:
6
)
Abstract:
The effects of natural antioxidants on nitric oxide (NO) modulation and oxidative status were determined in rat epithelial lung cells (L-2). Cells were stimulated with cytokines and treated with one of the following: resveratrol, soybean saponin group B (SSB), quercetin, genistein, olive leaf polyphenol concentrate (OLPC), or N-acetyl-L-cystein (NAC). NAC had no effect on NO levels, whereas resveratrol and OLPC were found to be effective in reducing nitrite levels, modifying iNOS mRNA, and decreasing free radical production. OLPC affected the levels of MnSOD while resveratrol did not, indicating that they act via different pathways. Quercetin and genistein reduced nitrite levels without affecting iNOS levels, presumably by scavenging NO. SSB did not affect nitrite levels, but exposure did reduce iNOS mRNA expression and protein levels, possibly due to antioxidant activity. Naturally occuring antioxidants, in particular resveratrol and OLPC, may have therapeutic potential in the treatment of inflammatory diseases. © 2005 American Chemical Society.
Note:
Related Files :
Animal
Animals
antioxidants
biosynthesis
Glycine max
metabolism
molecular genetics
Resveratrol
RNA
עוד תגיות
תוכן קשור
More details
DOI :
10.1021/jf052000u
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
23477
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:59
Scientific Publication
Natural compounds derived from foods modulate nitric oxide production and oxidative status in epithelial lung cells
53
Zaslaver, M., Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Offer, S., Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Kerem, Z., Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Stark, A.H., Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Weller, J.I., Department of Quantitative and Molecular Genetics, Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Israel
Eliraz, A., Pulmonary Unit, Kaplan Hospital, Rehovot, Israel
Madar, Z., Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Natural compounds derived from foods modulate nitric oxide production and oxidative status in epithelial lung cells
The effects of natural antioxidants on nitric oxide (NO) modulation and oxidative status were determined in rat epithelial lung cells (L-2). Cells were stimulated with cytokines and treated with one of the following: resveratrol, soybean saponin group B (SSB), quercetin, genistein, olive leaf polyphenol concentrate (OLPC), or N-acetyl-L-cystein (NAC). NAC had no effect on NO levels, whereas resveratrol and OLPC were found to be effective in reducing nitrite levels, modifying iNOS mRNA, and decreasing free radical production. OLPC affected the levels of MnSOD while resveratrol did not, indicating that they act via different pathways. Quercetin and genistein reduced nitrite levels without affecting iNOS levels, presumably by scavenging NO. SSB did not affect nitrite levels, but exposure did reduce iNOS mRNA expression and protein levels, possibly due to antioxidant activity. Naturally occuring antioxidants, in particular resveratrol and OLPC, may have therapeutic potential in the treatment of inflammatory diseases. © 2005 American Chemical Society.
Scientific Publication
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