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Inhibition of casein and fat synthesis and α-lactalbumin secretion by progesterone in explants from bovine lactating mammary glands
Year:
1987
Source of publication :
Journal of Endocrinology
Authors :
שמאי, אבי
;
.
Volume :
113
Co-Authors:
Shamay, A., Department of Agricultural Biochemistry, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Zeelon, E., Department of Agricultural Biochemistry, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Ghez, Z., Department of Agricultural Biochemistry, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Cohen, N.
Mackinlay, A.G.
Gertler, A.
Facilitators :
From page:
81
To page:
88
(
Total pages:
8
)
Abstract:
The effect of progesterone on casein and fat synthesis, on α-lactalbumin secretion and on accumulation of casein mRNA was studied in explants from bovine lactating mammary glands, cultured in the presence of insulin, cortisol or prolactin. All four biological activities were inhibited down to or below the level obtained in medium without prolactin. However, inhibition was only achieved by using concentrations of progesterone exceeding by 1000-fold those required for similar effects in tissue from non-lactating animals. A similar inhibitory effect was also found using high levels of other steroids without 11β-hydroxyl, such as deoxycorticosterone and dehydroepiandrosterone, and to some extent with oestradiol-17β, but not with cortisol or corticosterone. The inhibition by progesterone did not result from a decrease in explant viability, as determined by glucose uptake.
Note:
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DOI :
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Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
23846
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:03
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Scientific Publication
Inhibition of casein and fat synthesis and α-lactalbumin secretion by progesterone in explants from bovine lactating mammary glands
113
Shamay, A., Department of Agricultural Biochemistry, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Zeelon, E., Department of Agricultural Biochemistry, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Ghez, Z., Department of Agricultural Biochemistry, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Cohen, N.
Mackinlay, A.G.
Gertler, A.
Inhibition of casein and fat synthesis and α-lactalbumin secretion by progesterone in explants from bovine lactating mammary glands
The effect of progesterone on casein and fat synthesis, on α-lactalbumin secretion and on accumulation of casein mRNA was studied in explants from bovine lactating mammary glands, cultured in the presence of insulin, cortisol or prolactin. All four biological activities were inhibited down to or below the level obtained in medium without prolactin. However, inhibition was only achieved by using concentrations of progesterone exceeding by 1000-fold those required for similar effects in tissue from non-lactating animals. A similar inhibitory effect was also found using high levels of other steroids without 11β-hydroxyl, such as deoxycorticosterone and dehydroepiandrosterone, and to some extent with oestradiol-17β, but not with cortisol or corticosterone. The inhibition by progesterone did not result from a decrease in explant viability, as determined by glucose uptake.
Scientific Publication
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