trans-2-Cyanocycloalkanols: Versatile synthons for alicyclic cis- and trans-1,3-amino alcohols

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פותח על ידי קלירמאש פתרונות בע"מ -

trans-2-Cyanocycloalkanols: Versatile synthons for alicyclic cis- and trans-1,3-amino alcohols

Year: 

1991

Source of publication :

Synthesis

Authors :

הניג, הלמוט

.

Co-Authors: 

Fulop, F., Institute of Pharmaceutical Chemotherapy, Albert Szent-Gyorgyi Medical University, POB 121, H-6701 Szeged, Hungary
Huber, I., Institute of Pharmaceutical Chemotherapy, Albert Szent-Gyorgyi Medical University, POB 121, H-6701 Szeged, Hungary
Bernath, G., Institute of Pharmaceutical Chemotherapy, Albert Szent-Gyorgyi Medical University, POB 121, H-6701 Szeged, Hungary
Honig, H., Institute of Pharmaceutical Chemotherapy, Albert Szent-Gyorgyi Medical University, POB 121, H-6701 Szeged, Hungary
Seufer-Wasserthal, P., Institute of Pharmaceutical Chemotherapy, Albert Szent-Gyorgyi Medical University, POB 121, H-6701 Szeged, Hungary

From page: 

43

To page: 

46

(

Total pages: 

4

)

Link :

trans-2-Cyanocycloalkanols: Versatile synthons for alicyclic cis- and trans-1,3-amino alcohols

Abstract: 

From trans-2-hydroxycyclopentanecarbonitrile (1) and trans-2-hydroxycyclohexanecarbonitrile (2), a number of trans-2-aminomethylcycloalkanols are prepared by reductive alkylation. Inversion of trans-N-acylaminocycloalkanols by treatment with thionyl chloride and subsequent hydrolysis gives the cis counterparts. The enantiomerically pure trans-2-aminomethylcyclohexanols 13 and 14 are also prepared.